1,1-Dioxo-2,3-dihydro-1-benzothiophene-5-sulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 1,1-Dioxo-2,3-dihydro-1-benzothiophene-5-sulfonamide
• 化学式: C₈H₉NO₄S₂
• 分子量: 247.3
• InChiKey: GOJOHNHFAAEGSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] BENZO[b] THIOPHENE SULFONAMIDE-1, 1-DIOXIDE DERIVATIVES AND THEIR USE AS ANTINEOPLASTIC AGENTS<br/>[FR] DERIVES DE BENZO[b] THIOPHENE SULFONAMIDE-1, 1-DIOXIDE ET LEUR UTILISATION COMME AGENTS ANTINEOPLASIQUES
  申请人：UNIV NAVARRA PUBLICA

  公开号：WO2000063202A2

  公开（公告）日：2000-10-26

  Compounds of formula (I) or (II) wherein: n is 1 or 2; R4 and R5 each represents hydrogen or C1-C3 alkyl; and each R may be in position 4, 5, 6, or 7 of the benzothiophene ring and independently represents hydrogen; a halogen; C1-C3 alkyl; or a group -SO2Y, in whch Y represents a group -NR1R2, a group -NHCOOR3, -NHCONH2 or a group -NHCONHR3 in which R1 and R2 are independently hydrogen, C1-C3 alkyl or aryl, and R3 is C1-C3 alkyl or aryl; with the proviso that one and only one R represents a group -SO2Y; are useful in the treatment of cancerous tumours.