3-(1,3-benzodioxol-5-yl)-N,N-dimethyl-2,3-dihydro-1H-inden-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 3-(1,3-benzodioxol-5-yl)-N,N-dimethyl-2,3-dihydro-1H-inden-1-amine
• 化学式: C₁₈H₁₉NO₂
• 分子量: 281.3
• InChiKey: PTPIVPHHADFGNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Aminoindane derivatives as serotonin and norepinephrine uptake inhibitors
  申请人：Bogeso P Klaus

  公开号：US20050085530A1

  公开（公告）日：2005-04-21

  The present invention relates to aminoindane derivatives having the formula I wherein X, Y, U, R 1-2 , R 13-16 and R are as defined in the claims, or an acid addition salt thereof. The compounds of the invention posses the combined effect of serotonin reuptake inhibition and norepinephrine uptake inhibition.

  本发明涉及具有公式I的氨基茚衍生物，其中X，Y，U，R1-2，R13-16和R如权利要求中所定义，或其酸加成盐。本发明的化合物具有血清素再摄取抑制和去甲肾上腺素摄取抑制的联合作用。
• Aminoindane Derivatives As Serotonin And Norepinephrine Uptake Inhibitors
  申请人：Bogeso Klaus Peter

  公开号：US20080119547A1

  公开（公告）日：2008-05-22

  The present invention relates to aminoindane derivatives having the formula I wherein X, Y, U, R 1-2 , and R 13-16 are as defined in the claims, or an acid addition salt thereof. The compounds of the invention posses the combined effect of serotonin reuptake inhibition and norepinephrine uptake inhibition.

  本发明涉及具有公式I的氨基茚衍生物，其中X、Y、U、R1-2和R13-16如权利要求所定义，或其酸加成盐。本发明的化合物具有血清素重摄取抑制和去甲肾上腺素摄取抑制的综合效应。
• AMINOINDANE DERIVATIVES AS SEROTONIN AND NOREPINEPHRINE UPTAKE INHIBITORS
  申请人：H. Lundbeck A/S

  公开号：EP1458704A1

  公开（公告）日：2004-09-22
• US7351734B2
  申请人：——

  公开号：US7351734B2

  公开（公告）日：2008-04-01
• [EN] AMINOINDANE DERIVATIVES AS SEROTONIN AND NOREPINEPHRINE UPTAKE INHIBITORS<br/>[FR] DERIVES AMINOINDANE UTILISES COMME INHIBITEURS DE LA CAPTURE DE LA SEROTONINE ET DE LA NOREPINEPHRINE
  申请人：LUNDBECK & CO AS H

  公开号：WO2003055873A1

  公开（公告）日：2003-07-10

  The present invention relates to aminoindane derivatives having the formula I wherein X, Y, U, R?1-2, R13-16¿ and R are as defined in the claims, or an acid addition salt thereof. The compounds of the invention posses the combined effect of serotonin reuptake inhibition and norepinephrine uptake inhibition.