(Z)-but-2-enedioate;(3Z)-N-(2-hydroxy-3-piperidin-1-ium-1-ylpropoxy)pyridin-1-ium-3-carboximidoyl chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (Z)-but-2-enedioate;(3Z)-N-(2-hydroxy-3-piperidin-1-ium-1-ylpropoxy)pyridin-1-ium-3-carboximidoyl chloride
• 化学式: C18H24ClN3O6
• 分子量: 413.9
• InChiKey: RPNGOMBXNOMBCG-LXGYEFRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.56
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  133
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• [EN] HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE MOLECULAR CHAPERON PRODUCTION AND THE PREPARATION THEREOF<br/>[FR] DERIVES D'HYDROXYLAMINE UTILISES POUR AMELIORER LA PRODUCTION DE CHAPERONS MOLECULAIRES ET LEUR PREPARATION
  申请人：BIOREX KUTATÓ ÉS FEJLESZTÓ RT.

  公开号：WO1997016439A1

  公开（公告）日：1997-05-09

  (EN) A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, a hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which a hydroxylamine derivative is administered is a eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.(FR) Procédé visant à accroître l'expression d'un chaperon moléculaire par une cellule et/ou à intensifier l'activité de celui-ci dans les cellules. Le procédé consiste à traiter une cellule qui est exposée à une tension physiologique induisant l'expression d'un chaperon moléculaire par la cellule avec une quantité efficace d'un certain dérivé d'hydroxylamine afin d'augmenter la tension. Selon une autre variante, un dérivé d'hydroxylamine peut être administré à une cellule avant d'être exposé à une tension physiologique induisant l'expression d'un chaperon moléculaire par la cellule. De préférence, la cellule dans laquelle est administré le dérivé d'hydroxylamine est une cellule eucaryote. Le dérivé d'hydroxylamine correspond aux formules (I) et (II). L'invention se rapporte également à des nouveaux dérivés d'hydroxylamine relevant des formules (I) et (II), ainsi qu'à des compositions pharmaceutiques et/ou cosmétiques comprenant ces composés.

  本发明提供了一种增加细胞分子伴侣表达和/或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理受到诱导细胞分子伴侣表达的生理压力的细胞，以增加压力。或者，在细胞暴露于诱导细胞分子伴侣表达的生理压力之前，可以向细胞中注入羟胺衍生物。最好注入羟胺衍生物的细胞是真核细胞。该羟胺衍生物对应于式（I）或（II）。本发明还提供了在式（I）和（II）范围内的新的羟胺衍生物，以及包含这些化合物的药物和/或化妆品组合物。
• Method of enhancing cellular production of molecular chaperon, hydroxylamine derivatives useful for enhancing the chaperon production and the preparation thereof
  申请人：Biorex Research & Development Co.

  公开号：US20040067940A1

  公开（公告）日：2004-04-08

  A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

  提供了一种通过细胞增加分子伴侣表达和/或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理受到诱导细胞分子伴侣表达的生理应激的细胞，以增加应激。或者，在细胞暴露于诱导其表达分子伴侣的生理应激之前，可以向细胞施用羟胺衍生物。最好，施用羟胺衍生物的细胞是真核细胞。羟胺衍生物对应于式(I)或(II)。该发明还提供了落在式(I)和(II)范围内的新羟胺衍生物，以及包含上述化合物的药物和/或化妆品组合物。
• METHOD OF ENHANCING CELLULAR PRODUCTION OF MOLECULAR CHAPERONE, HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE CHAPERONE PRODUCTION AND THE PREPARATION THEREOF
  申请人：Vígh László

  公开号：US20100267711A1

  公开（公告）日：2010-10-21

  A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

  本发明提供了一种通过细胞增加分子伴侣的表达和/或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理受到诱导细胞分子伴侣表达的生理应激的细胞，以增加应激。或者，在细胞暴露于诱导其表达分子伴侣的生理应激之前，可以向细胞中注入羟胺衍生物。最好，接受羟胺衍生物处理的细胞是真核细胞。羟胺衍生物对应于公式（I）或（II）。本发明还提供了落在公式（I）和（II）范围内的新羟胺衍生物，以及包含该化合物的药物和/或化妆品组合物。
• Heat shock proteins and cholesterol homeostasis
  申请人：Orphazyme A/S

  公开号：US10898476B2

  公开（公告）日：2021-01-26

  Provided herewith are bioactive agents that increase the intracellular concentration and/or activity of one or more heat shock proteins, including Hsp70, for use in the treatment of a disease associated with dysregulation of cholesterol homeostasis.

  本文提供的生物活性剂可提高一种或多种热休克蛋白（包括 Hsp70）的细胞内浓度和/或活性，用于治疗与胆固醇平衡失调有关的疾病。
• Substituted triazolopyridazines
  申请人：MERRELL PHARMACEUTICALS INC.

  公开号：EP0441339B1

  公开（公告）日：1997-08-20