6-(3-pyrrolidin-1-ylpropoxy)-7-methoxy-4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]quinazoline | 263400-31-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-(3-pyrrolidin-1-ylpropoxy)-7-methoxy-4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]quinazoline
• 英文别名: N-[3-[[7-methoxy-6-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-yl]amino]-4-methylphenyl]-2-morpholin-4-ylpyridine-4-carboxamide
• CAS: 263400-31-3
• 化学式: C₃₃H₃₉N₇O₄
• 分子量: 597.717
• InChiKey: NLGJQAZZCYQANQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  44
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Substituted anilino-quinoline compounds and use thereof
  申请人：ASTRAZENECA AB

  公开号：US20030216417A1

  公开（公告）日：2003-11-20

  The invention concerns amide derivatives of Formula (I), wherein: G is N or CH; R 1 is a group such as hydroxy, halo, trifluoromethyl, C 1-6 alkyl and C 1-6 alkoxy; each of R 2 and R 3 is hydrogen, halo, C 1-6 alkyl, C 2-6 alkenyl or C 2-6 alkynyl; R 4 is a group such as hydrogen, hydroxy, C 1-6 alkyl, C 1-6 alkoxy and C 3-7 cycloalkyl, or R 4 is of the Formula (IC): —K-J, wherein J is aryl, heteroaryl or heterocyclyl and K is a bond or a group such as oxy and imino, R 5 is a group such as hydrogen, halo and trifluoromethyl; m is 1-3 and q is 0-4; or pharmaceutically acceptable salts or in vivo cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

  本发明涉及公式（I）的酰胺衍生物，其中：G为N或CH；R1为羟基、卤素、三氟甲基、C1-6烷基和C1-6烷氧基等基团；R2和R3中的每一个是氢、卤素、C1-6烷基、C2-6烯基或C2-6炔基；R4为氢、羟基、C1-6烷基、C1-6烷氧基和C3-7环烷基等基团，或者R4为公式（IC）中的基团：—K-J，其中J为芳基、杂芳基或杂环基，K为键或氧和亚胺等基团；R5为氢、卤素和三氟甲基等基团；m为1-3，q为0-4；或其药学上可接受的盐或体内可水解的酯。本发明还涉及制备这些化合物的方法、含有它们的制药组合物以及它们在治疗由细胞因子介导的疾病或医疗情况中的用途。
• QUINOLINE AND QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CYTOKINE MEDIATED DISEASES
  申请人：AstraZeneca AB

  公开号：EP1117653B1

  公开（公告）日：2003-02-05
• CHEMICAL COMPOUNDS
  申请人：AstraZeneca AB

  公开号：EP1117653A1

  公开（公告）日：2001-07-25
• US6593333B1
  申请人：——

  公开号：US6593333B1

  公开（公告）日：2003-07-15
• US6716847B2
  申请人：——

  公开号：US6716847B2

  公开（公告）日：2004-04-06