[2-Amino-4-[(4-fluorophenyl)methylamino]phenyl]carbamic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-Amino-4-[(4-fluorophenyl)methylamino]phenyl]carbamic acid
• 化学式: C₁₄H₁₄FN₃O₂
• 分子量: 275.28
• InChiKey: YVYBOBCEEPIDJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  87.4
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Derivatives of 1,3-diamino benzene as potassium channel modulators
  申请人：Vernier Jean-Michel

  公开号：US20080045534A1

  公开（公告）日：2008-02-21

  This invention provides compounds of formula I where X═O or S; Y is O or S; q=1 or 0; and other substituents are defined herein. The invention also provides pharmaceutical compositions comprising compounds of formula I. Such compounds are potassium channel modulators.

  本发明提供了公式I的化合物 其中X=O或S；Y为O或S；q=1或0；其他取代基在此定义。本发明还提供了包含公式I化合物的药物组合物。这样的化合物是钾通道调节剂。
• N-[2-AMINO-4-(PHENYLMETHOXY)PHENYL] AMIDES AND RELATED COMPOUNDS AS POTASSIUM CHANNEL MODULATORS
  申请人：Vernier Jean-Michel

  公开号：US20080188561A1

  公开（公告）日：2008-08-07

  This invention provides compounds of formula A and formula B which are modulators of potassium ion channels and are useful for the treatment of seizure disorders.

  这项发明提供了公式A和公式B的化合物，它们是钾离子通道的调节剂，可用于治疗癫痫症。
• Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
  申请人：Vernier Jean-Michel

  公开号：US20080139610A1

  公开（公告）日：2008-06-12

  This invention provides a compound of formula IA where X═O or S; Y is O or S; q=1 or 0; and other substituents are defined herein. Such compounds can affect the opening of, or otherwise modulate, voltage-gated potassium channels. They are potentially useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.

  这项发明提供了一种化合物，其化学式为IA，其中X═O或S；Y为O或S；q=1或0；其他取代基在此处有定义。这些化合物可以影响开放或调节电压门控钾通道，潜在用于治疗和预防受钾离子通道激活或调节影响的疾病和疾病。一种这样的病症是癫痫症。
• BENZYLOXY ANILIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS
  申请人：Wu Jim Zhen

  公开号：US20090326059A1

  公开（公告）日：2009-12-31

  The present invention relates to benzyloxyanilide derivatives having the following structural formula: The compounds of the present invention are useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.

  本发明涉及具有以下结构式的苯甲氧基苯胺衍生物：本发明的化合物可用于治疗和预防受钾离子通道激活或调节影响的疾病和疾病。其中一种病症是癫痫症。
• DERIVATIVES OF 4-(N-AZACYCLOALKYL) ANILIDES AS POTASSIUM CHANNEL MODULATORS
  申请人：VERNIER Jean-Michel

  公开号：US20080318979A1

  公开（公告）日：2008-12-25

  This invention provides potassium channel modulators which are compounds of formula I where at least one of W and Z is N; where the moiety is one of Groups A or B below A where Ar is a 1,2-fused, six membered ring aromatic group, bearing substituents R 1 and R 2 as defined below, and containing zero or one ring nitrogen atom; and where other substituents are defined herein. The invention also provides a composition comprising a pharmaceutically acceptable carrier and at least one of the following: i) a pharmaceutically effective amount of a compound of formula I and ii) a pharmaceutically acceptable salt, ester, or prodrug thereof. The invention also provides a method of preventing or treating a disease or disorder which is affected by activities of potassium channels, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula I or a salt, ester, or prodrug thereof.

  这项发明提供了钾通道调节剂，其化合物为公式I，其中W和Z中至少有一个是N；其中基团为下面的A或B之一： A 其中Ar是一个1,2-融合的六元环芳香基团，带有以下定义的取代基R1和R2，并含有零个或一个环氮原子；其他取代基在此处定义。 该发明还提供了一种组合物，包括一种药学上可接受的载体和以下至少一种：i) 公式I的化合物的药学有效量，以及ii) 其药学上可接受的盐、酯或前药。 该发明还提供了一种预防或治疗受钾通道活动影响的疾病或紊乱的方法，包括向有需要的患者施用公式I的化合物或其盐、酯或前药的治疗有效量。