3-[(E)-2-phenylethenyl]-6-(piperidin-1-ylmethyl)-5,6-dihydro-2H-1,2,4-oxadiazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[(E)-2-phenylethenyl]-6-(piperidin-1-ylmethyl)-5,6-dihydro-2H-1,2,4-oxadiazine
• 化学式: C₁₇H₂₃N₃O
• 分子量: 285.4
• InChiKey: OVDQZUMDVUYCBI-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  36.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof , and pharmaceutical compositions containing the same
  申请人：——

  公开号：US20030153559A1

  公开（公告）日：2003-08-14

  The invention refers to novel propenecarboxylic acid amidoxime derivatives furthermore N-oxides and/or geometrical isomers and/or optical isomers and/or pharmaceutically suitable acid addition salts and/or quaternary derivatives thereof. The novel compounds are suitable for the treatment of a state connected with oxygen deficit and/or energy deficit, or a disease based on PARP inhibition, especially an autoimmune or neurodegenerative disease, and/or a viral disease, and/or a disease caused by a toxic effect.

  本发明涉及新型丙烯羧酸脒肟衍生物，以及其 N-氧化物和/或几何异构体和/或光学异构体和/或药用酸加成盐和/或季衍生物。这些新型化合物适用于治疗与缺氧和/或能量不足有关的状态，或基于 PARP 抑制的疾病，尤其是自身免疫性疾病或神经退行性疾病，和/或病毒性疾病，和/或由毒性作用引起的疾病。
• Propenecarboxylic acid amidoxime derivatives, a process for the preparation thereof, and pharmaceutical compositions containing the same
  申请人：Literati Nagy Peter

  公开号：US20050165019A1

  公开（公告）日：2005-07-28

  The invention refers to novel propenecarboxylic acid amidoxime derivatives furthermore N-oxides and/or geometrical isomers and/or optical isomers and/or pharmaceutically suitable acid addition salts and/or quaternary derivatives thereof. The novel compounds are suitable for the treatment of a state connected with oxygen deficit and/or energy deficit, or a disease based on PARP inhibition, especially an autoimmune or neurodegenerative disease, and/or a viral disease, and/or a disease caused by a toxic effect.

  本发明涉及新型丙烯羧酸脒肟衍生物，以及其 N-氧化物和/或几何异构体和/或光学异构体和/或药用酸加成盐和/或季衍生物。这些新型化合物适用于治疗与缺氧和/或能量不足有关的状态，或基于 PARP 抑制的疾病，尤其是自身免疫性疾病或神经退行性疾病，和/或病毒性疾病，和/或由毒性作用引起的疾病。
• PROPENECARBOXYLIC ACID AMIDOXIME DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
  申请人：N-Gene Research Laboratories Inc.

  公开号：EP1268407A1

  公开（公告）日：2003-01-02
• US6887872B2
  申请人：——

  公开号：US6887872B2

  公开（公告）日：2005-05-03
• US7151175B2
  申请人：——

  公开号：US7151175B2

  公开（公告）日：2006-12-19