2-Tert-butyl-5-(4-cyclohexylphenyl)phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Tert-butyl-5-(4-cyclohexylphenyl)phenol
• 化学式: C₂₂H₂₈O
• 分子量: 308.5
• InChiKey: SBOJHPPPGHIHPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Process for the preparation of phenylphenol compounds
  申请人：——

  公开号：US20030191349A1

  公开（公告）日：2003-10-09

  There is described the preparation of phenylphenol compounds of formula (I) by reaction of a keto compound of formula (3) with dioxolane of formula (4) and with an ammonium compound of formula (5) to form a &bgr;-aminoketone compound of formula (6) (reaction step (I)), reaction of the compound of formula (6) with a compound of formula (7) to form a compound of formula (2) (reaction step (II)), and subsequent alkylation to form a compound of formula (I) (reaction step (III)) in accordance with scheme (A); wherein R 1 , R 2 , R 3 , R 6 and R 7 are each independently of the others hydrogen or C 1 -C 8 -alkyl; R 4 , R 5 and R 8 are each independently of the others hydrogen or C 1 -C 5 alkyl; and Hal is a halogen atom. The compounds prepared in accordance with the invention are suitable as antimicrobial active substances. 1 2

  本发明描述了通过将化合物的酮基化合物(3)与二氧六环化合物(4)和铵化合物(5)反应，形成β-氨基酮化合物(6)（反应步骤(I)），将化合物(6)与化合物(7)反应形成化合物(2)（反应步骤(II)），然后进行烷基化形成化合物(I)（反应步骤(III)）的方法，其中R1、R2、R3、R6和R7分别独立地为氢或C1-C8-烷基；R4、R5和R8分别独立地为氢或C1-C5烷基；Hal为卤素原子。根据方案(A)制备的化合物适用作为抗微生物活性物质。
• PROCESS FOR THE PREPARATION OF PHENYLPHENOL COMPOUNDS
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1313689A1

  公开（公告）日：2003-05-28
• US6753451B2
  申请人：——

  公开号：US6753451B2

  公开（公告）日：2004-06-22
• [EN] PROCESS FOR THE PREPARATION OF PHENYLPHENOL COMPOUNDS<br/>[FR] PROCEDE DE PREPARATION DE COMPOSES PHENYLPHENOL
  申请人：CIBA SC HOLDING AG

  公开号：WO2002018311A1

  公开（公告）日：2002-03-07

  There is described the preparation of phenylphenol compounds of formula (1) by reaction of a keto compound of formula (3) with dioxolane of formula (4) and with an ammonium compound of formula (5) to form a β-aminoketone compound of formula (6) (reaction step (I)), reaction of the compound of formula (6) with a compound of formula (7) to form a compound of formula (2) (reaction step (II)), and subsequent alkylation to form a compound of formula (1) (reaction step (III)) in accordance with scheme (A); wherein R1, R2, R3, R6 and R7 are each independently of the others hydrogen or C1-C8alkyl; R4, R5 and R8 are each independently of the others hydrogen or C1-C5alkyl; and Hal is a halogen atom. The compounds prepared in accordance with the invention are suitable as antimicrobial active substances.