2-(4-cyanophenyl)-6-(4-pyridyl)pyrimidin-4-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-cyanophenyl)-6-(4-pyridyl)pyrimidin-4-one
• 英文别名: 4-(6-oxo-4-pyridin-4-yl-1H-pyrimidin-2-yl)benzonitrile
• 化学式: C₁₆H₁₀N₄O
• 分子量: 274.282
• InChiKey: QSOBXSOXDKUKQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PYRIMIDONE DERIVATIVES
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP1115721B1

  公开（公告）日：2003-12-10
• US7256199B1
  申请人：——

  公开号：US7256199B1

  公开（公告）日：2007-08-14
• [EN] PYRIMIDONE DERIVATIVES<br/>[FR] DERIVES PYRIMIDONE
  申请人：MITSUBISHI CHEM CORP

  公开号：WO2000018758A1

  公开（公告）日：2000-04-06

  A pyrimidone derivative represented by formula (I) or a salts thereof: wherein R1 represents an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group and the like; R2 represents a hydrogen atom, hydroxyl group, an alkyl group, an alkenyl group and the like, R3 represents a pyridyl group, and a medicament comprising said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase l hyperactivity such as Alzheimer disease.