2-(4-ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro-pyridazin-3-one | 183582-64-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-ethoxycarbonylaminobenzyl)-6-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro-pyridazin-3-one
• 英文别名: ethyl N-[4-[[3-(3,4-dimethoxyphenyl)-6-oxo-4,5-dihydropyridazin-1-yl]methyl]phenyl]carbamate
• CAS: 183582-64-1
• 化学式: C₂₂H₂₅N₃O₅
• 分子量: 411.458
• InChiKey: RQPOEGOXCVKURG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  89.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR<br/>[FR] AGENTS DE MODULATION DE LA DIFFERENCIATION ET UTILISATIONS ASSOCIEES
  申请人：UNIV QUEENSLAND

  公开号：WO2005065686A1

  公开（公告）日：2005-07-21

  This invention discloses methods and agents for modulating the differentiation potential and/or proliferation of preadipocytes. More particularly, the present invention discloses methods and agents for modulating a fibroblast growth factor (FGF) signalling pathway, especially the FGF-1 or FGF-2 signalling pathway, for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma and lipomatosis.

  该发明揭示了调节前脂肪细胞分化潜能和/或增殖的方法和药剂。更具体地，本发明揭示了调节成纤维细胞生长因子（FGF）信号通路的方法和药剂，特别是FGF-1或FGF-2信号通路，用于治疗或预防与脂肪相关的疾病，包括但不限于肥胖、脂肪瘤和脂肪增生。
• Arylalkylpyridazinones
  申请人：MERCK KGAA

  公开号：US20020111356A1

  公开（公告）日：2002-08-15

  Aralkylpyridazinone derivatives of the formula I 1 and their physiologically acceptable salts in which R 1 , R 2 , R 3 , R 4 , R 5 and Q have the meanings indicated in claim 1, show inhibition of phosphodiesterase IV and can be employed for the treatment of inflammatory processes and of allergies, asthma and autoimmune disorders.

  公式I1的Aralkylpyridazinone衍生物及其生理上可接受的盐，其中R1，R2，R3，R4，R5和Q具有声明1中指示的含义，显示出对磷酸二酯酶IV的抑制作用，可用于治疗炎症过程以及过敏，哮喘和自身免疫性疾病。
• Methods for treating asthmatic conditions
  申请人：Wyeth

  公开号：US20030149029A1

  公开（公告）日：2003-08-07

  This invention provides methods for treating in mammals asthma and asthmatic conditions using substituted indole compounds of the general formula: 1 and pharmaceutically acceptable salt forms thereof, and methods for using the compounds as inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A 2 enzymes, and for the medical treatment, prevention and inhibition of pain and inflammation.

  本发明提供了一种使用通式为1的取代吲哚化合物及其药学上可接受的盐形式，治疗哮喘和哮喘症状的哺乳动物的方法，并且提供了使用这些化合物作为各种磷脂酶酶活性抑制剂的方法，特别是磷脂酶A2酶的方法，以及用于医疗治疗、预防和抑制疼痛和炎症的方法。
• Inhibitors of cytosolic phospholipase A2
  申请人：McKew C. John

  公开号：US20070004719A1

  公开（公告）日：2007-01-04

  This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A 2 enzymes (cPLA 2 ), more particularly including inhibitors of cytosolic phospholipase A 2 alpha enzymes (cPLA 2 α). In some embodiments, the inhibitors have the Formula I: wherein the constituent variables are as defined herein.

  该发明提供了化学抑制剂，用于抑制各种磷脂酶酶活性，特别是细胞质磷脂酶A2酶（cPLA2），更特别地包括细胞质磷脂酶A2α酶（cPLA2α）的抑制剂。在某些实施例中，抑制剂具有公式I，其中组成变量如本文所定义。
• Inhibitors of Cytosolic Phospholipase A2
  申请人：McKew John C.

  公开号：US20100022536A1

  公开（公告）日：2010-01-28

  This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A 2 enzymes (cPLA 2 ), more particularly including inhibitors of cytosolic phospholipase A 2 alpha enzymes (cPLA 2 α). In some embodiments, the inhibitors have the Formula I: wherein the constituent variables are as defined herein.

  该发明提供了化学抑制剂，用于抑制各种磷脂酶酶的活性，特别是细胞质磷脂酶A2酶（cPLA2），更特别地包括细胞质磷脂酶A2α酶（cPLA2α）的抑制剂。在某些实施例中，抑制剂具有公式I：其中组分变量如此处所定义。