[[2-Bromo-4-[(3-phenoxyphenyl)methoxymethyl]phenyl]-difluoromethyl]phosphonic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [[2-Bromo-4-[(3-phenoxyphenyl)methoxymethyl]phenyl]-difluoromethyl]phosphonic acid
• 化学式: C₂₁H₁₈BrF₂O₅P
• 分子量: 499.2
• InChiKey: ZLLSABJEKKHNNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Aryldifluoromethylphosphonic acids for treatment of diabetes
  申请人：——

  公开号：US20040176330A1

  公开（公告）日：2004-09-09

  The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. 1 The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing PTP-1B mediated diseases, including diabetes.

  本发明涵盖了以下公式所代表的新型化合物类别，这些化合物是PTP-1B酶的抑制剂。此外，本发明还涵盖了包括上述化合物的药物组合物以及治疗或预防PTP-1B介导的疾病，包括糖尿病的方法。
• US7163932B2
  申请人：——

  公开号：US7163932B2

  公开（公告）日：2007-01-16
• [EN] ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS FOR TREATMENT OF DIABETES<br/>[FR] ACIDES ARYLDIFLUOROMETHYLPHOSPHONIQUES POUR LE TRAITEMENT DE DIABETES
  申请人：MERCK FROSST CANADA INC

  公开号：WO2002102813A1

  公开（公告）日：2002-12-27

  The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme (Formula I). The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing PTP-1B mediated diseases, including diabetes.