3-[[5-chloro-2-[[[2-(morpholino)ethylamino]carbonyl]oxy]phenyl]methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[[5-chloro-2-[[[2-(morpholino)ethylamino]carbonyl]oxy]phenyl]methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one
• 英文别名: 3-[[5-Chloro-2-[[[2-(morpholino)ethylamino]carbonyl]oxyl]phenyl]-methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one；[4-chloro-2-[[2-oxo-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-3-yl]methyl]phenyl] N-(2-morpholin-4-ylethyl)carbamate
• 化学式: C₂₃H₂₂ClF₃N₄O₅
• 分子量: 526.9
• InChiKey: URJDLGVPTYLUSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  92.7
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• CARBAMATE DERIVATIVES OF DIARYL 1,3,4-OXADIAZOLONE
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP1150978A1

  公开（公告）日：2001-11-07
• EP1150978A4
  申请人：——

  公开号：EP1150978A4

  公开（公告）日：2002-06-12
• US6162817A
  申请人：——

  公开号：US6162817A

  公开（公告）日：2000-12-19
• US6297241B1
  申请人：——

  公开号：US6297241B1

  公开（公告）日：2001-10-02
• [EN] CARBAMATE DERIVATIVES OF DIARYL 1,3,4-OXADIAZOLONE<br/>[FR] DERIVES CARBAMATES DE 1,3,4-OXADIAZOLONE DIARYLE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2000044745A1

  公开（公告）日：2000-08-03

  The present invention provides novel carbamate oxadiazolone derivatives having general formula (I) wherein R?1 and R2¿ are as defined herein, or a nontoxic pharmaceutically acceptable salt or solvate thereof and are useful in the treatment of disorders which are responsive to the opening of the large conductance calcium-activated potassium channels.