5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide;5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide;5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
• 化学式: C47H55ClN4O10S2
• 分子量: 935.5
• InChiKey: UUTOBRJMWBGUOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.02
• 重原子数：
  64
• 可旋转键数：
  13
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  232
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• Hyperbranched polyglycerol-coated particles and methods of making and using thereof
  申请人：Yale University

  公开号：US10238581B2

  公开（公告）日：2019-03-26

  Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. The shell is formed of or contains hyperbranched polyglycerol (HPG). The HPG coating can be modified to adjust the properties of the particles. Unmodified HPG coatings impart stealth properties to the particles which resist non-specific protein absorption and increase circulation in the blood. The hydroxyl groups on the HPG coating can be chemically modified to form functional groups that react with functional groups and adhere the particles to tissue, cells, or extracellular materials, such as proteins.

  本文描述了核壳微粒及其制造和使用方法。内核由一种或多种疏水性材料或多种疏水性材料形成或含有这些材料。壳由超支化聚甘油（HPG）形成或含有超支化聚甘油（HPG）。可以对 HPG 涂层进行改性，以调整颗粒的特性。未经改性的 HPG 涂层可赋予微粒隐形特性，从而阻止非特异性蛋白质的吸收，并促进血液循环。HPG 涂层上的羟基可进行化学修饰，形成与官能团反应的官能团，将微粒粘附到组织、细胞或蛋白质等细胞外物质上。
• Nanoscale multiple emulsions and nanoparticles
  申请人：The Regents of the University of California

  公开号：US11254773B2

  公开（公告）日：2022-02-22

  Nanoscale multiple emulsions, nanoparticles resulting therefrom and methods of making and using thereof are described. The nanoscale multiple emulsions are typically double nanoemulsions, such as oil-in-water-in-oil (O1/W/O2) nanoemulsions, in which nanodroplets of the first oil (O1) phase are suspended in the aqueous (W) phase and together are dispersed in the second oil (O2) phase. The double nanoemulsions are stable with high encapsulation efficiency allowing templating to form multiphase nanoparticles. The multiphase nanoparticles include nanodroplets of O1 phase dispersed in a continuous matrix that can be a liquid, a gel, or a solid at room temperature and pressure. Methods of making the double nanoemulsions include high-energy forces and serial nanoemulsifications.

  本文描述了纳米级多重乳液、由此产生的纳米颗粒及其制造和使用方法。纳米级多重乳液通常是双纳米乳液，如油包水（O1/W/O2）纳米乳液，其中第一油相（O1）的纳米微滴悬浮在水相（W）中，并一起分散在第二油相（O2）中。双纳米乳液稳定，封装效率高，可模板化形成多相纳米粒子。多相纳米颗粒包括分散在连续基质中的 O1 相纳米微滴，该基质在室温和压力下可以是液体、凝胶或固体。制造双纳米乳剂的方法包括高能量力和连续纳米乳化。
• TETRAHYDROPYRIMIDONE INHIBITORS OF FATTY ACID BINDING PROTEIN AND METHOD
  申请人：Bristol-Myers Squibb Co.

  公开号：EP1253925A1

  公开（公告）日：2002-11-06
• HYPERBRANCHED POLYGLYCEROL-COATED PARTICLES AND METHODS OF MAKING AND USING THEREOF
  申请人：Yale University

  公开号：EP3140269A1

  公开（公告）日：2017-03-15
• MICRODEVICES WITH COMPLEX GEOMETRIES
  申请人：Massachusetts Institute of Technology

  公开号：EP3681486A1

  公开（公告）日：2020-07-22