3,4-Dimethyl-1-(7-oxonon-8-enyl)pyrrole-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3,4-Dimethyl-1-(7-oxonon-8-enyl)pyrrole-2,5-dione
• 化学式: C₁₅H₂₁NO₃
• 分子量: 263.33
• InChiKey: NSONMNWQJAWKHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  54.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Hydrogels and hydrogel arrays made from reactive prepolymers crosslinked by [2 + 2] cycloaddition
  申请人：Motorola, Inc.

  公开号：US20020115740A1

  公开（公告）日：2002-08-22

  Reactive prepolymers incorporating [2+2] photoreactive sites are synthesized. Upon exposure to UV light, these prepolymers undergo [2+2] cycloaddition to crosslink. When crosslinked, the reactive prepolymers form a hydrogel. Selective hydrogel formation is provided through selective exposure of the reactive prepolymer to UV light. Supports and other molecules may be attached or incorporated into the hydrogel through [2+2] cycloaddition with uncrosslinked [2+2] photoreactive sites present in the hydrogel.

  合成了包含【2+2】光反应位点的反应性预聚物。在紫外光的照射下，这些预聚物会发生【2+2】环加成反应，形成交联物。交联后，反应性预聚物形成了一种水凝胶。通过选择性地将反应性预聚物暴露在紫外光下，可以提供选择性水凝胶形成。支撑物和其他分子可以通过与水凝胶中存在未交联的【2+2】光反应位点的环加成反应来附着或纳入到水凝胶中。
• POLYACRYLAMIDE HYDROGELS AND HYDROGEL ARRAYS MADE FROM POLYACRYLAMIDE REACTIVE PREPOLYMERS
  申请人：——

  公开号：US20020035167A1

  公开（公告）日：2002-03-21

  The present invention provides polyacrylamide hydrogels (especially polyacrylamide hydrogel arrays) made from prepolymers and polyacrylamide reactive polymers, as well as methods and compositions for preparing the polyacrylamide hydrogels or hydrogel arrays. The method advantageously provides greater control of polyacrylamide pore size and crosslink density, allowing, for instance, preparation of a polyacrylamide hydrogel appropriate for use with DNA. Furthermore, the methods and compositions can be employed in commercial processes.

  本发明提供了由预聚物和聚丙烯酰胺活性聚合物制成的聚丙烯酰胺水凝胶（特别是聚丙烯酰胺水凝胶阵列），以及制备聚丙烯酰胺水凝胶或水凝胶阵列的方法和组合物。这种方法的优点是可以更好地控制聚丙烯酰胺的孔径和交联密度，例如可以制备出适合 DNA 使用的聚丙烯酰胺水凝胶。此外，这些方法和组合物可用于商业工艺中。
• Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays
  申请人：Motorola Inc.

  公开号：US20030078314A1

  公开（公告）日：2003-04-24

  The present invention provides solid supports (e.g., glass) and polymer hydrogels (particularly polymer hydrogel arrays present on a solid support) comprising one or more reactive sites for the attachment of biomolecules, as well as biomolecules comprising one or more reactive sites for attachment to solid supports and polymer hydrogels. The invention further provides novel compositions and methods for the preparation of biomolecules, solid supports, and polymer hydrogels comprising reactive sites. The invention also provides for preparation of crosslinked solid supports, polymer hydrogels, and hydrogel arrays, wherein one or more biomolecules is attached by means of the reactive sites in a photocycloaddition reaction. Advantageously, according to the invention, crosslinking of the hydrogel and attachment of biomolecules can be done in a single step.

  本发明提供了包含一个或多个用于附着生物分子的反应位点的固体支持物（如玻璃）和聚合物水凝胶（特别是存在于固体支持物上的聚合物水凝胶阵列），以及包含一个或多个用于附着到固体支持物和聚合物水凝胶的反应位点的生物分子。本发明进一步提供了制备包含反应位点的生物大分子、固体支持物和聚合物水凝胶的新型组合物和方法。本发明还提供了交联固体支持物、聚合物水凝胶和水凝胶阵列的制备方法，其中一种或多种生物大分子通过光环加成反应中的反应位点附着。有利的是，根据本发明，水凝胶的交联和生物分子的附着可在一个步骤中完成。
• ATTACHMENT OF BIOMOLECULE TO A POLYMERIC SOLID SUPPORT BY CYCLOADDITION OF A LINKER
  申请人：MOTOROLA INC.

  公开号：EP1190254A2

  公开（公告）日：2002-03-27
• US6391937B1
  申请人：——

  公开号：US6391937B1

  公开（公告）日：2002-05-21