1-(3-Methylphenyl)-3-(6-nitro-1,3-benzothiazol-2-yl)urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-Methylphenyl)-3-(6-nitro-1,3-benzothiazol-2-yl)urea
• 化学式: C15H12N4O3S
• 分子量: 328.3
• InChiKey: JYTQQABBMZMHDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  128
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• UREA DERIVATIVES FOR TREATING AND/OR PREVENTING CANCER
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

  公开号：US20210380547A1

  公开（公告）日：2021-12-09

  The present invention relates to a compound or a pharmaceutically acceptable salt thereof of formulae (I) and (II), and a pharmaceutical composition comprising such compound for use for treating a cancer, particularly a cancer overexpressing CXCR1 and CXCR2 receptors, such as medulloblastoma, head and neck and kidney cancer. The invention further relates to such compounds for use for treating macular degeneration.
• [EN] UREA DERIVATIVES FOR TREATING AND/OR PREVENTING CANCER<br/>[FR] DÉRIVÉS D'URÉE POUR LE TRAITEMENT ET/OU LA PRÉVENTION DU CANCER
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2020079184A2

  公开（公告）日：2020-04-23

  The present invention relates to a compound or a pharmaceutically acceptable salt thereof of formulae (I) and (II), and a pharmaceutical composition comprising such compound for use for treating a cancer, particularly a cancer overexpressing CXCR1 and CXCR2 receptors, such as medulloblastoma, head and neck and kidney cancer. The invention further relates to such compounds for use for treating macular degeneration.