4-Pyrrolidin-1-yl-2-(trifluoromethyl)benzonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 4-Pyrrolidin-1-yl-2-(trifluoromethyl)benzonitrile
• 化学式: C₁₂H₁₁F₃N₂
• mdl: MFCD11038275
• 分子量: 240.22
• InChiKey: XGBCYEBSNWBRGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Selective androgen receptor modulators (SARMs) and uses thereof
  申请人：Ligand Pharmaceuticals Incorporated

  公开号：US11358931B2

  公开（公告）日：2022-06-14

  Provided herein are compounds, such as compounds of Formula I, that bind to androgen receptors and/or modulate activity of androgen receptors. Also provided are methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.

  本文提供了与雄激素受体结合和/或调节雄激素受体活性的化合物，如式 I 化合物。还提供了制造和使用此类化合物的方法。还提供了包括此类化合物的组合物以及制造和使用此类组合物的方法。
• SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF
  申请人：Ligand Pharmaceuticals Incorporated

  公开号：US20200361866A1

  公开（公告）日：2020-11-19

  Provided herein are compounds that bind to androgen receptors and/or modulate activity of androgen receptors. Also provided are methods for making and using such compounds. Also provided are compositions including such compounds and methods for making and using such compositions.
• [EN] CRYSTALLINE FORMS AND METHODS OF PRODUCING CRYSTALLINE FORMS OF A COMPOUND<br/>[FR] FORMES CRISTALLINES ET PROCÉDÉS DE PRODUCTION DE FORMES CRISTALLINES D'UN COMPOSÉ
  申请人：LIGAND PHARM INC

  公开号：WO2020214834A1

  公开（公告）日：2020-10-22

  Disclosed herein are methods of crystallizing the compound of Formula (I), as well as crystalline forms thereof. Crystalline forms of Formula (I) disclosed include crystalline Form C, crystalline Form E, and Crystalline form B.