2-Acetyloxy-5-(nitrooxymethyl)benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Acetyloxy-5-(nitrooxymethyl)benzoic acid
• 化学式: C10H9NO7
• 分子量: 255.18
• InChiKey: VFPRJQGYIRYMJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  119
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Anti-inflammatory and anti-thrombotic compounds and their compositions
  申请人：Zhang Don

  公开号：US20050148554A1

  公开（公告）日：2005-07-07

  The invention encompasses novel compounds of Formula I, which are anti-inflammatory and anti-thrombotic agents. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenases (COX-1 and COX-2) mediated diseases comprising the use of compounds of Formula I. The above compounds may be used as a combination therapy with low-dose aspirin, NSAIDs, or selective COX-2 inhibitors to treat chronic cyclooxygenases mediated diseases or conditions while simultaneously reducing the risk of thrombotic cardiovascular events.

  本发明涵盖了式I的新化合物，它们是抗炎和抗血栓剂。本发明还涵盖了某些药物组合和治疗环氧合酶（COX-1和COX-2）介导疾病的方法，包括使用式I的化合物。上述化合物可以与低剂量阿司匹林、NSAIDs或选择性COX-2抑制剂一起使用，以治疗慢性COX介导的疾病或病况，同时降低血栓性心血管事件的风险。
• [EN] ANTI-INFLAMMATORY AND ANTI-THROMBOTIC COMPOUNDS AND THEIR COMPOSITIONS<br/>[FR] COMPOSES ANTI-INFLAMMATOIRES ET ANTITHROMBOTIQUES ET LEURS COMPOSITIONS
  申请人：BETA PHARMA INC

  公开号：WO2004062598A2

  公开（公告）日：2004-07-29

  The invention encompasses compounds of Formula (I), which are antis inflammatory and anti-thrombotic agents. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenases (COX-1 and COX-2) mediated diseases comprising the use of compounds of Formula (I). The above compounds may be used as a combination therapy with low-dose aspirin, NSAIDs, or selective COX-2 inhibitors to treat chronic cyclooxygenases mediated diseases or conditions while simultaneously reducing the risk of thrombotic cardiovascular events.