N-ethyl-N-(2-hydroxy-3-sul-fopropyl)-3,5-dimethylaniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-ethyl-N-(2-hydroxy-3-sul-fopropyl)-3,5-dimethylaniline
• 英文别名: 3-(N-ethyl-3,5-dimethylanilino)-2-hydroxypropane-1-sulfonic acid
• 化学式: C₁₃H₂₁NO₄S
• 分子量: 287.38
• InChiKey: CDGBQMHYFARRCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Peptides, methods for assaying human pepsinogen I or human pepsin I and assay kits
  申请人：——

  公开号：US20020099019A1

  公开（公告）日：2002-07-25

  Peptides of the formula (I) R-X-ProlleGlu-W-Y-Z  (I) (wherein R is hydrogen, an amino-protective group, residue carrying one or two D- or L-amino acid, X is Lys or Arg, W is Phe orPhe(NO 2 ) (in which Phe(NO 2 ) is p-nitrophenylalanine.), Y is Phe, Phe(NO 2 ), Tyr, 3,5-diiodotyrosine, norleucine, Leu, Asp(OBzl) or Met (in which OBzl is benzyloxy.), Z is an aniline, aminocoumarin or aminonaphthalene derivative residue.), or acid addition salts thereof. Peptides of the formula (I) are specific substrates for human pepsin I, so they are used in assaying human pepsin I or human pepsinogen I. These peptide are useful in the diagnosis of gastric diseases such as gastric cancer and gastric ulcer.

  公式（I）的肽(R-X-ProlleGlu-W-Y-Z) (其中R是氢，氨基保护基，残基携带一个或两个D-或L-氨基酸，X是Lys或Arg，W是Phe或Phe(NO2)（其中Phe(NO2)是对硝基苯丙氨酸。），Y是Phe，Phe(NO2)，Tyr，3,5-二碘酪氨酸，norleucine，Leu，Asp(OBzl)或Met（其中OBzl是苄氧基），Z是苯胺，氨基香豆素或氨基萘衍生物残基），或其酸加成盐。公式（I）的肽是人胃蛋白酶I的特异性底物，因此它们用于检测人胃蛋白酶I或人胃蛋白酶原I。这些肽对于诊断胃癌和胃溃疡等胃病非常有用。
• METHOD FOR MEASURING TRIGLYCERIDE IN LOW-DENSITY LIPOPROTEIN AND KIT FOR MEASUREMENT
  申请人：Katayama Yuki

  公开号：US20090226944A1

  公开（公告）日：2009-09-10

  The present invention provides a method for a simple and accurate measurement of triglycerides in low-density lipoprotein in a sample comprising performing the following steps sequentially: (i) a step of generating free glycerol by allowing lipoprotein lipase to act on a sample, in an aqueous medium comprising the sample and a specific surfactant such as polyoxyethylene polyoxyalkylene polycyclic phenyl ether; (ii) a step of removing free glycerol present in the reaction solution of the above step (i); (iii) a step of generating free glycerol by allowing lipoprotein lipase to act on the reaction solution from which free glycerol has been removed in step (ii), in the presence of a specific surfactant such as polyoxyethylene polyoxyalkylene alkyl ether; and (iv) a step of measuring free glycerol generated in step (iii), and a kit used for the method.

  本发明提供了一种简单准确地测量样品中低密度脂蛋白中甘油三酯的方法，包括按照以下步骤顺序进行：(i)在包括样品和特定表面活性剂（例如聚氧乙烯聚氧烷基多环苯醚）的水介质中，使脂蛋白酯酶作用于样品，生成游离甘油；(ii)去除步骤(i)中反应溶液中存在的游离甘油；(iii)在去除步骤(ii)中的游离甘油的反应溶液中，使脂蛋白酯酶作用于特定表面活性剂（例如聚氧乙烯聚氧烷基烷基醚）的存在下，生成游离甘油；(iv)测量步骤(iii)中生成的游离甘油，以及用于该方法的试剂盒。
• OXIDATIVE CHROMOGENIC COMPOUND OR SALT THEREOF AND PRODUCTION METHOD THEREOF, AND REAGENT COMPOSITION AND TEST INSTRUMENT USING THE SAME
  申请人：Kawanishi Tetsuro

  公开号：US20100062464A1

  公开（公告）日：2010-03-11

  It is an object of the present invention to provide a means for measuring a concentration of various components rapidly with high accuracy and high sensitivity. The present invention is to provide an oxidative chromogenic compound or salt thereof represented by the following chemical formula (1): wherein R 1 and R 2 are each independently a linear or branched alkyl group having 1 to 5 carbon atoms; R 3 , R 4 , R 5 , R 6 and R 7 are each independently a hydrogen atom, a carboxyl group or a sulfonic acid group, or salt thereof, provided that at least one of R 3 to R 7 is a carboxyl group or a sulfonic acid group, or salt thereof, and the others are hydrogen atoms, and the production method thereof, and the reagent composition and test instrument using the same.

  本发明的目的是提供一种快速、高精度和高灵敏度测量各种成分浓度的手段。本发明提供了一种氧化性显色化合物或其盐，其化学式如下（1）：其中R1和R2分别是具有1至5个碳原子的线性或支链烷基；R3、R4、R5、R6和R7分别是氢原子、羧基或磺酸基，或其盐，但至少其中之一是羧基或磺酸基，或其盐，其余为氢原子，以及其生产方法、试剂组成和使用该试剂组成的测试仪器。
• Process for determining substrate or enzymatic activity
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：EP0121254A2

  公开（公告）日：1984-10-10

  A process for quantitavely determining a substrate or enzyme activity in a body fluid can be carried out with high accuracy without any influence of interfering substance by adding to a sample a first reagent solution comprising 2-naphthol or a derivative thereof, peroxidase, an oxidase, and if necessary one or more substances for producing a substrate or used as substrates for the oxidase and the like, adding to the resulting mixture a second reagent solution comprising 4-amino-antipyrine, a developer, and an enzyme necessary for producing the same substance as giving an error to the determination of substrate, or one or more substances used as substrates for the enzyme to be determined, followed by colorimetrical determination.

  向样品中加入由 2-萘酚或其衍生物、过氧化物酶、氧化酶组成的第一试剂溶液，以及 必要时加入一种或多种用于产生底物或用作氧化酶底物的物质、向产生的混合物中加入第二试剂溶液，第二试剂溶液由 4-氨基安替比林、显影剂和产生与底物测定产生误差的物质所需的酶或用作待测定酶底物的一种或多种物质组成，然后进行比色测定。
• PROCESS FOR DECOMPOSING ASCORBIC ACID
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：EP0148275A1

  公开（公告）日：1985-07-17

  A novel process for decomposing ascorbic acid to produce H2O and dehydroascorbic acid instead of producing H2O2 which comprises mixing a monovalent or divalent copper ion, peroxidase, and at least one compound selected from the group consisting of: (1) 4-aminoantipyrine; (2) 3-methylbenzothiazolinone hydrazone; (3) 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid); (4) triphenylmethane leuco dyes; (5) phenolic compounds; (6) aniline compounds; and (7) naphthol compounds.

  一种分解抗坏血酸以产生 H2O 和脱氢抗坏血酸而不是产生 H2O2 的新工艺，它包括将一价或二价铜离子、过氧化物酶和至少一种选自以下组别的化合物混合在一起：(1) 4-氨基安替比林；(2) 3-甲基苯并噻唑啉酮腙；(3) 2,2'-偶氮双(3-乙基苯并噻唑啉-6-磺酸)；(4) 三苯甲烷白基染料；(5) 酚类化合物；(6) 苯胺化合物；(7) 萘酚化合物。