5-(3-cyclopentyloxy-4-methoxyphenyl)pyridine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-(3-cyclopentyloxy-4-methoxyphenyl)pyridine-2-carboxamide
• 英文别名: 5-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyridinecarboxamide
• 化学式: C₁₈H₂₀N₂O₃
• 分子量: 312.368
• InChiKey: POJMHKGLNMKGTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  74.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyridine-2-carbonyl chloride 在 氨 作用下， 以 二氯甲烷 为溶剂， 生成 5-(3-cyclopentyloxy-4-methoxyphenyl)pyridine-2-carboxamide
  参考文献：
  名称：

  Biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-α

  摘要：

  Tumor necrosis factor-alpha (TNF-alpha) has been implicated as a key mediator in the progression of rheumatoid arthritis. Inhibitors of phosphodiesterase IV (PDE IV) have been shown to inhibit the production of TNF-alpha by elevating intracellular levels of cyclic adenosine monophosphate (cAMP). Our efforts in a series of biarylcarboxamides have led to the identification of 8j (CP-353,164) as a potent inhibitor of PDE IV and TNF-alpha production. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00097-8

文献信息

• Tissue reactive compounds and compositions and uses thereof
  申请人：Angiotech International AG

  公开号：US20040219214A1

  公开（公告）日：2004-11-04

  A composition comprising a synthetic polymer, optionally in the presence of a drug, where the polymer comprises multiple activated groups. The multiple activated groups are reactive with functionality present on animal tissue, so that upon administration of the polymer to the tissue, the polymer binds to the tissue. Alternatively, the multiple activated groups are reactive with functionality present on a non-living surface, where the polymer binds to this surface to, e.g., increase the lubricity of the surface. When drug is present in the composition, the drug is then delivered to the site of polymer attachment.

  一种组合物包括一种合成聚合物，可选地存在药物，并且该聚合物包括多个活性基团。这些多个活性基团与动物组织上存在的功能性反应，因此在将聚合物注射到组织中时，聚合物与组织结合。或者，这些多个活性基团与非生物表面上存在的功能性反应，聚合物将与该表面结合，例如增加表面的润滑性。当组合物中存在药物时，药物将被传递到聚合物附着的部位。
• Soft tissue implants and anti-scarring agents
  申请人：Hunter L. William

  公开号：US20050142162A1

  公开（公告）日：2005-06-30

  Soft tissue implants (e.g., breast, pectoral, chin, facial, lip, and nasal implants) are used in combination with an anti-scarring agent in order to inhibit scarring that may otherwise occur when the implant is placed within an animal.

  软组织植入物（例如乳房、胸肌、下巴、面部、唇部和鼻部植入物）与抗瘢痕剂结合使用，以抑制动物体内植入物放置时可能发生的瘢痕形成。
• Methods of inducing ovulation using a non-polypeptide camp level modulator
  申请人：Laboratoires Serono SA

  公开号：EP1908463A2

  公开（公告）日：2008-04-09

  The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.

  本发明涉及诱导雌性宿主排卵的方法，包括向雌性宿主施用非多肽环磷酸腺苷（cAMP）水平调节剂。在另一方面，本发明提供了在宿主排卵周期的黄体期之前特异性给药磷酸二酯酶抑制剂的方法。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同工酶抑制剂。
• Drug delivery from rapid gelling polymer composition
  申请人：ANGIOTECH INTERNATIONAL AG

  公开号：EP2181704A2

  公开（公告）日：2010-05-05

  Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in prevention of surgical adhesions.

  本发明公开了一些组合物，这些组合物由两部分聚合物组成，在混合在一起时可迅速形成共价连接，从而实现药物输送。当需要快速粘附组织和形成凝胶并同时给药时，这种组合物特别适合用于各种与组织相关的应用。例如，这种组合物可用作组织密封剂、促进止血、实现组织粘合、提供组织增量以及防止手术粘连。
• Methods of inducing ovulation
  申请人：——

  公开号：US20020103106A1

  公开（公告）日：2002-08-01

  The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.

  本发明涉及诱导雌性宿主排卵的方法，包括向雌性宿主施用非多肽环磷酸腺苷（cAMP）水平调节剂。在另一方面，本发明提供了在宿主排卵周期的黄体期之前特异性给药磷酸二酯酶抑制剂的方法。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同工酶抑制剂。