6-(bis-(4-Ethoxy)phenyl)methyl-2-phenyl-pyrimidine-4-ol | 269395-15-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-(bis-(4-Ethoxy)phenyl)methyl-2-phenyl-pyrimidine-4-ol
• 英文别名: 4-[bis(4-ethoxyphenyl)methyl]-2-phenyl-1H-pyrimidin-6-one
• CAS: 269395-15-5
• 化学式: C₂₇H₂₆N₂O₃
• 分子量: 426.515
• InChiKey: BHFIUSHSKXEIBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  59.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• US6518424B1
  申请人：——

  公开号：US6518424B1

  公开（公告）日：2003-02-11
• [EN] SUBSTITUTED PYRIMIDINE COMPOSITIONS AND METHODS OF USE<br/>[FR] COMPOSITIONS DE PYRIMIDINES A SUBSTITUTION ET MODES D'UTILISATION
  申请人：ELAN PHARM INC

  公开号：WO2000027824A1

  公开（公告）日：2000-05-18

  Substituted pyrimidines that have general structure (I) in which the symbol R1 represents a C¿1?-C6 alkyl, C1-C6 alkoxy or halogen atom; R?2¿ represents a phenyl group, substituted phenyl group, benzyl moiety, substituted benzyl moiety, C¿3?-C7 cycloalkyl, or substituted C3-C7 cycloalkyl; R?3¿ represents a hydrogen or C¿1?-C6 alkyl group; R?4¿ represents -H, -OH, -N¿3? or -NHCOCH3; and R?5¿ represents H are provided. These compounds have activity as inhibitors of phospholipase A¿2?, and are useful in treating disorders mediated by phospholipase A2.