2,3-Bis[(2-chlorobenzoyl)oxy]butanedioic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-Bis[(2-chlorobenzoyl)oxy]butanedioic acid
• 化学式: C₁₈H₁₂Cl₂O₈
• 分子量: 427.2
• InChiKey: XJKOBLMFKCDMLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Process for the resolution of racemic verapamil
  申请人：Bertolotti Chiara

  公开号：US20080306296A1

  公开（公告）日：2008-12-11

  A new process is described for the resolution of racemic verapamil, which allows the desired enantiomer to be obtained in high yields and with high enantiomeric purity. The process uses optically active 2,3-bis[(2-fluorobenzoyl)oxy]butanedioic acid as the resolving agent, and a water/dimethylformamide or water/acetonitrile or water/methanol mixture, as the reaction solvent.

  描述了一种新的过程，用于分离消旋维拉帕米尔，该过程允许以高产率和高对映纯度获得所需的对映体。该过程使用光学活性的2,3-双[(2-氟苯甲酰)氧基]丁二酸作为分离剂，以水/二甲基甲酰胺或水/乙腈或水/甲醇混合物作为反应溶剂。
• A process for the resolution of racemic verapamil
  申请人：Cosma S.p.A.

  公开号：EP2014644A1

  公开（公告）日：2009-01-14

  A new process is described for the resolution of racemic verapamil, which allows the desired enantiomer to be obtained in high yields and with high enantiomeric purity. The process uses optically active 2,3-bis[(2-fluorobenzoyl)oxy]butanedioic acid as the resolving agent, and a water/dimethylformamide or water/acetonitrile or water/methanol mixture, as the reaction solvent.

  本文介绍了一种新的方法，用于分离混合物中的顺-异维拉帕米尔，该方法可以高产率地获得所需的对映体，并具有高的对映选择性。该过程使用具有光学活性的2,3-双[(2-氟苯甲酰)氧基]丁二酸作为分离剂，以及水/二甲基甲酰胺或水/乙腈或水/甲醇混合物作为反应溶剂。
• Production of 0,0'-diacyltartaric acid crystals
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0924188A1

  公开（公告）日：1999-06-23

  Crystals of an aromatic 0,0'-diacyltartaric acid of the formula (VIII): wherein R2 and R3 are the same as or different from one another and each is a hydrogen atom, halogen atom or C1 - C4 alkyl group are sufficiently uniform in size that 95% to 98% of them pass through a 20-mesh sieve. Such crystals may be prepared by hydrolyzing an aromatic carboxylic anhydride of the formula (IV): wherein R2 and R3 are as defined above, to form the corresponding acid (VIII) in the form of an oil and crystallizing the acid in the presence of an organic solvent which is immiscible with water to form crystals of the hydrate of the acid (VIII). For the crystallization process, each of the organic solvent immiscible with water and seed crystals of the acid (VIII) are added to the oil of the acid (VIII) present in the reaction mixture.

  式（VIII）的芳香族 0,0'-二酰酒石酸晶体： 其中 R2 和 R3 彼此相同或不同，且各自为氢原子、卤素原子或 C1 - C4 烷基，其大小足够均匀，95%-98% 的晶体可通过 20 目筛。这种晶体可以通过水解式（IV）的芳香族羧酸酐来制备： 其中 R2 和 R3 如上定义，形成油状的相应酸 (VIII)，并在与水不溶的有机溶剂存在下使酸结晶，形成酸 (VIII) 的水合物晶体。在结晶过程中，将不溶于水的有机溶剂和酸 (VIII) 的种子晶体分别加入反应混合物中存在的酸 (VIII) 油中。
• Process for preparing D-alloisoleucine and intermediates for preparation
  申请人：YAMAKAWA CHEMICAL INDUSTRY CO., LTD.

  公开号：EP0937705A2

  公开（公告）日：1999-08-25

  Disclosed are a novel process for preparing D-alloisoleucine and an improved process for epimerizing L-isoleucine to prepare D-alloisoleucine. In the former process, (2S, 3S)-tartaric acid derivative of formula I below; wherein R stands for a hydrogen atom, a C1-C3 lower alkyl group, lower alkoxy group, chlorine atom, bromine atom and nitro group; and "n" is a number of 0, 1 and 2; is combined with an epimer mixture of L-isoleucine and D-alloisoleucine in a reaction medium to form a complex of D-alloisoleucine and the compound of formula I. The precipitated complex is decomposed by putting it in an alcohol to isolate D-alloisoleucine. In the latter process, L-isoleucine is suspended in an inert solvent which does not substantially dissolve amino acids, and epimerized in the presence of C1-C5 saturated lower fatty acid and salicylaldehyde

  本发明公开了一种制备 D-别异亮氨酸的新工艺，以及一种将 L-异亮氨酸外嵌化以制备 D-别异亮氨酸的改进工艺。在前一种工艺中，下式 I 的（2S，3S）-酒石酸衍生物；其中 R 代表氢原子、C1-C3 低级烷基、低级烷氧基、氯原子、溴原子和硝基；"n "是 0、1 和 2 的数字；在反应介质中与 L-异亮氨酸和 D-异亮氨酸的外嵌混合物结合，形成 D-异亮氨酸和式 I 化合物的复合物。将沉淀的复合物放入醇中分解，分离出 D-异亮氨酸。在后一种工艺中，将 L-异亮氨酸悬浮在一种基本上不溶解氨基酸的惰性溶剂中，并在 C1-C5 饱和低级脂肪酸和水杨醛的存在下进行表聚。
• Process for producing O,O'-diacyltartaric anhydride and process for producing O,O'-diacyltartaric acid
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0600714B1

  公开（公告）日：1999-08-18