4-chloro-N-(4-cyano-1-{[(cyanoimino)(3-pyridinylamino)methyl]amino}-2,2-diethylbutyl)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-N-(4-cyano-1-{[(cyanoimino)(3-pyridinylamino)methyl]amino}-2,2-diethylbutyl)benzamide
• 英文别名: 4-chloro-N-[4-cyano-1-[[(cyanoamino)-(pyridin-3-ylamino)methylidene]amino]-2,2-diethylbutyl]benzamide
• 化学式: C₂₃H₂₆ClN₇O
• 分子量: 451.959
• InChiKey: RGQNJIIWPCTVRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  126
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Potassium channel openers
  申请人：——

  公开号：US20020028836A1

  公开（公告）日：2002-03-07

  Compounds of formula I: 1 are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

  公式I的化合物： 1 在治疗通过或用钾通道开放剂预防或改善的疾病中是有用的。还公开了钾通道开放组合物以及在哺乳动物中开放钾通道的方法。
• POTASSIUM CHANNEL OPENERS
  申请人：Abbott Laboratories

  公开号：EP1198456A2

  公开（公告）日：2002-04-24
• US6645968B2
  申请人：——

  公开号：US6645968B2

  公开（公告）日：2003-11-11
• [EN] POTASSIUM CHANNEL OPENERS<br/>[FR] AGENTS D'OUVERTURE DES CANAUX POTASSIQUES
  申请人：ABBOTT LAB

  公开号：WO2001009096A2

  公开（公告）日：2001-02-08

  Compounds of formula (I), are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
• [EN] POTASSIUM CHANNEL OPENERS<br/>[FR] OUVREURS DE CANAUX POTASSIQUES
  申请人：ABBOTT LAB

  公开号：WO2002062762A2

  公开（公告）日：2002-08-15

  Compounds of formula (I) are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.