DIBRT

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: DIBRT
• 英文别名: 3,5-dibromo-4-(3',5'-diisopropyl-4'-hydroxyphenoxy) benzoic acid；3,5-Dibromo-4-[4-hydroxy-3,5-bis(propan-2-yl)phenoxy]benzoic acid；3,5-dibromo-4-[4-hydroxy-3,5-di(propan-2-yl)phenoxy]benzoic acid
• 化学式: C₁₉H₂₀Br₂O₄
• 分子量: 472.173
• InChiKey: PFUQJKKBXJZCRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• COMPOSITIONS OF DUAL THYROINTEGRIN ANTAGONISTS AND USE IN VASCULAR-ASSOCIATED DISORDERS
  申请人：Mousa Shaker A.

  公开号：US20110105482A1

  公开（公告）日：2011-05-05

  A dual thyrointegrin antagonist and a method for treating an angiogenesis-mediated disorder and/or a hyperthyroidism disorders by introducing the dual thyrointegrin antagonist into animals (e.g., mammals, human beings). The dual thyrointegrin antagonist includes a chemical structure having a thyroid hormone antagonist and αvβ 3 integrin antagonist in the same molecule.

  一种双重甲状腺整合素拮抗剂及其治疗介导血管生成障碍和/或甲状腺功能亢进症的方法，通过将双重甲状腺整合素拮抗剂引入动物（例如哺乳动物、人类）来实现。双重甲状腺整合素拮抗剂包括一种具有甲状腺激素拮抗剂和αvβ3整合素拮抗剂的化学结构在同一分子中。
• Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists and formulations and uses thereof
  申请人：Mousa Shaker A.

  公开号：US20090022806A1

  公开（公告）日：2009-01-22

  Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.

  本发明涉及治疗与血管生成有关的疾病的方法，包括向受试者施用有效量的聚合物纳米粒子形式的甲状腺激素激动剂、部分激动剂或其拮抗剂，以促进或抑制受试者的血管生成。本发明还涉及聚合物形式的甲状腺激素或甲状腺激素类似物的组合物。
• Nuclear receptor ligands and ligand binding domains
  申请人：Baxter D. John

  公开号：US20070027215A1

  公开（公告）日：2007-02-01

  The present invention provides new methods, particularly computational methods, and compositions for the generation of nuclear receptor synthetic ligands based on the three dimensional structure of nuclear receptors, particularly the thyroid receptor (herein referred to as “TR”). Also provided are crystals, nuclear receptor synthetic ligands, and related methods.

  本发明提供了新的方法，特别是计算方法和组合物，用于基于核受体的三维结构，特别是甲状腺受体（以下简称“TR”）生成核受体合成配体。还提供了晶体、核受体合成配体和相关方法。
• Nanoparticle and Polymer Formulations for Thyroid Hormone Analogs, Antagonists, and Formulations and Uses Thereof
  申请人：Davis Paul J.

  公开号：US20110142941A1

  公开（公告）日：2011-06-16

  Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric Nanoparticle form of thyroid hormone agonist, partial agonist or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.

  揭示了治疗与血管生成相关疾病的方法，包括给予有效量的聚合物纳米粒子形式的甲状腺激素激动剂、部分激动剂或其拮抗剂，以促进或抑制受试者的血管生成。还揭示了聚合物形式的甲状腺激素或甲状腺激素类似物的组成。
• EP0873361A4
  申请人：——

  公开号：EP0873361A4

  公开（公告）日：2002-10-23