2-fluoro-N-[[4-[[[2-(4-fluorophenyl)-3-pyridin-3-ylpropyl]amino]methyl]cyclohexyl]methyl]benzenesulfonamide;dihydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-fluoro-N-[[4-[[[2-(4-fluorophenyl)-3-pyridin-3-ylpropyl]amino]methyl]cyclohexyl]methyl]benzenesulfonamide;dihydrochloride
• 化学式: C28H35Cl2F2N3O2S
• 分子量: 586.6
• InChiKey: YYHVDILGBLDCHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  38
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  79.5
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Assessment of neurons in the arcuate nucleus to screen for agents that modify feeding behavior
  申请人：Cowley Michael

  公开号：US20050015820A1

  公开（公告）日：2005-01-20

  Screening methods of use in identifying agents that affect caloric intake, food intake, appetite, and energy expenditure are disclosed herein. These methods are used to identify agents of use in treating obesity, or that can be used to decrease the weight of a subject. These methods can also be used to identify agents of use in treating anorexia or cachexia and can be used to increase appetite and to increase the weight and lean body mass of a subject.

  本文公开了用于鉴定影响热量摄入、食物摄入、食欲和能量消耗的制剂的筛选方法。这些方法可用于鉴定治疗肥胖症或可用于减轻受试者体重的药物。这些方法还可用于确定治疗厌食症或恶病质的药物，并可用于增加食欲和增加受试者的体重和瘦体重。
• ASSESSMENT OF NEURONS IN THE ARCUATE NUCLEUS TO SCREEN FOR AGENTS THAT MODIFY FEEDING BEHAVIOR
  申请人：Cowley Michael

  公开号：US20080213803A1

  公开（公告）日：2008-09-04

  Screening methods of use in identifying agents that affect caloric intake, food intake, appetite, and energy expenditure are disclosed herein. These methods are used to identify agents of use in treating obesity, or that can be used to decrease the weight of a subject. These methods can also be used to identify agents of use in treating anorexia or cachexia and can be used to increase appetite and to increase the weight and lean body mass of a subject.
• MODIFICATION OF FEEDING BEHAVIOR
  申请人：Cowley Michael

  公开号：US20090209461A1

  公开（公告）日：2009-08-20

  Methods are disclosed for decreasing calorie intake, food intake, and appetite in a subject. The methods include peripherally administering a therapeutically effective amount of PYY or an agonist thereof to the subject, thereby decreasing the calorie intake of the subject.
• US6380224B1
  申请人：——

  公开号：US6380224B1

  公开（公告）日：2002-04-30
• US7919329B2
  申请人：——

  公开号：US7919329B2

  公开（公告）日：2011-04-05