1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone;1-[phenyl-(4-phenylphenyl)methyl]imidazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone;1-[phenyl-(4-phenylphenyl)methyl]imidazole
• 化学式: C48H46Cl2N6O4
• 分子量: 841.8
• InChiKey: IYPFQNGAFAVUBP-MHUAFMOUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.39
• 重原子数：
  60
• 可旋转键数：
  11
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  86.9
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• ANTIBACTERIAL COMBINATION THERAPY FOR THE TREATMENT OF GRAM POSITIVE BACTERIAL INFECTIONS
  申请人：e-Therapeutics plc

  公开号：EP2328573B1

  公开（公告）日：2014-08-27
• US8614179B2
  申请人：——

  公开号：US8614179B2

  公开（公告）日：2013-12-24
• [EN] ANTIBACTERIAL COMBINATION THERAPY FOR THE TREATMENT OF GRAM POSITIVE BACTERIAL INFECTIONS<br/>[FR] POLYTHÉRAPIE ANTIBACTÉRIENNE POUR LE TRAITEMENT D'INFECTIONS BACTÉRIENNES
  申请人：E THERAPEUTICS PLC

  公开号：WO2009081117A1

  公开（公告）日：2009-07-02

  There is described a composition comprising a therapeutically active imidazole, or a derivative thereof, and gemfibrozil, or a derivative thereof. There is also described a method of treating a subject suffering from an infection using such a composition.
• [EN] ANTIBACTERIAL COMBINATION THERAPY FOR THE TREATMENT OF GRAM POSITIVE BACTERIAL INFECTIONS<br/>[FR] THÉRAPIE ANTIBACTÉRIENNE DE COMBINAISON POUR TRAITEMENT D'INFECTIONS PAR BACTÉRIES GRAM POSITIVES
  申请人：E THERAPEUTICS PLC

  公开号：WO2010007381A1

  公开（公告）日：2010-01-21

  There is described a composition comprising a therapeutically active imidazole, and derivatives thereof, and an agent active on a bacterial cell surface selected from the group consisting of one or more of colistin, nisin, D-cycloserine, fosfomycin, fosfomycin trometamol, fosfomycin disodium and polymixin B, and derivatives thereof.