1-(3-cyano-phenyl)-tetrahydro-pyrrolo[1,2-a]imidazole-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-(3-cyano-phenyl)-tetrahydro-pyrrolo[1,2-a]imidazole-2,5-dione
• 英文别名: 3-(2,5-Dioxo-3,6,7,7a-tetrahydropyrrolo[1,2-a]imidazol-1-yl)benzonitrile
• 化学式: C₁₃H₁₁N₃O₂
• 分子量: 241.249
• InChiKey: LFWPAWVVOFABCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  64.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents
  申请人：Farina Carlo

  公开号：US20070027137A1

  公开（公告）日：2007-02-01

  Described herein are new bicyclic arylimidazolones having nootropic action (i.e., protecting and stimulating cerebral functions), analgesic action and anti hyperalgesic action; also described is the process for their preparation and pharmaceutical compositions comprising them, useful for the treatment of cognitive deficits, and of various types of pain.

  本文介绍了一种具有神经保护和刺激脑功能、镇痛作用和抗高痛敏作用的新型双环芳基咪唑酮；还描述了它们的制备过程和包含它们的制药组合物，用于治疗认知缺陷和各种类型的疼痛。
• Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof
  申请人：Farina Carlo

  公开号：US20100173945A1

  公开（公告）日：2010-07-08

  Described herein are new bicyclic arylimidazolones having nootropic action (i.e., protecting and stimulating cerebral functions), analgesic action and anti hyperalgesic action; also described is the process for their preparation and pharmaceutical compositions comprising them, useful for the treatment of cognitive deficits, and of various types of pain.

  本文介绍了一种新的双环芳基咪唑酮，具有促进和保护大脑功能的诺普利特作用，镇痛作用和抗高敏作用；还介绍了它们的制备过程和包含它们的制药组合物，用于治疗认知缺陷和各种类型的疼痛。
• Compounds with nootropic action, their preperation, pharmaceutical compositions containing them, and use thereof
  申请人：FARINA Carlo

  公开号：US20090163565A1

  公开（公告）日：2009-06-25

  Described herein are new bicyclic arylimidazolones having nootropic action (i.e., protecting and stimulating cerebral functions), analgesic action and anti hyperalgesic action; also described is the process for their preparation and pharmaceutical compositions comprising them, useful for the treatment of cognitive deficits, and of various types of pain.

  本文描述了一种具有神经保护和刺激脑功能、镇痛和抗高痛敏作用的新型双环芳基咪唑酮；还描述了它们的制备过程和包含它们的药物组合物，可用于治疗认知缺陷和各种类型的疼痛。
• Use of dimiracetam in the treatment of chronic pain
  申请人：Neurotune AG

  公开号：EP2620149A2

  公开（公告）日：2013-07-31

  The use of dimiracetam in the treatment of chronic pain chronic pain induced by osteoarthritis, rheumatoid arthritis or autoimmune osteoarthrosis forms is disclosed. At doses higher than those previously disclosed in relation with its cognition enhancing activity (i.e. amelioration of learning and memory), dimiracetam was able to completely revert hyperalgesia or allodynia associated with several animal models of chronic pain. Dimiracetam showed high activity in painful conditions caused by osteoarthritis. In addition, dimiracetam was devoid of toxicity even at doses 10-fold higher than the highest therapeutic dose. The possibility of treating such debilitating pathologies with a highly effective and essentially non-toxic compound is therefore disclosed.

  本研究公开了地米拉西坦在治疗由骨关节炎、类风湿性关节炎或自身免疫性骨关节病引起的慢性疼痛中的应用。在剂量高于之前披露的与认知增强活性（即改善学习和记忆）相关的剂量时，地米拉西坦能够完全恢复与几种慢性疼痛动物模型相关的痛觉过度或异动症。在骨关节炎引起的疼痛方面，地米拉西坦显示出很高的活性。此外，即使使用比最高治疗剂量高10倍的剂量，地米拉西坦也不会产生毒性。因此，这种高效且基本无毒的化合物可用于治疗此类使人衰弱的病症。
• PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS
  申请人：NIKEM RESEARCH S.R.L.

  公开号：EP1608655A2

  公开（公告）日：2005-12-28