2-[(Dimethylamino)methyl]-4,6-bis(2-methylpropyl)phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(Dimethylamino)methyl]-4,6-bis(2-methylpropyl)phenol
• 化学式: C₁₇H₂₉NO
• 分子量: 263.4
• InChiKey: HAQKSMMQBBRXSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Compositions and methods for treating hemorrhagic virus infections and other disorders
  申请人：——

  公开号：US20020077276A1

  公开（公告）日：2002-06-20

  Cytokine-receptor and cytokine antagonist-enriched blood-dervided compositions and methods of preparing and using the compositions are provided. Also provided are compositions and methods for the treatment or prevention of disorders, especially acute inflammatory disorders involving pathological responses of the immune system, such as viral hemorrhagic diseases, sepsis, rheumatoid arthritis and other autoimmune disorders, acute cardiovascular events, flare-ups and acute phases of multiple sclerosis, wasting disorders and other disorders involving deleterious expression of cytokines and other factors, including tumor necrosis factor (TNF) and interleukin-1 (IL-1) are provided.

  提供了富含细胞因子受体和细胞因子拮抗剂的血液衍生物组合物的制备和使用方法。还提供了用于治疗或预防疾病的组合物和方法，特别是涉及免疫系统病理反应的急性炎症性疾病，如病毒性出血热疾病、败血症、类风湿关节炎和其他自身免疫性疾病、急性心血管事件、多发性硬化的急性阶段、消耗性疾病和其他涉及细胞因子和其他因子有害表达的疾病，包括肿瘤坏死因子（TNF）和白细胞介素-1（IL-1）。
• Method of inhibiting interleukin-1 release
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0284879A2

  公开（公告）日：1988-10-05

  Methods useful for inhibiting the release of interleukin-1 and for alleviating interleukin-1 mediated conditions, such as IL-1-mediated inflammation, comprising administration of an effective amount of a pharmaceu­tically acceptable antioxidant compound such as disulfiram, tetrakis [3-(2,6-di-tert-butyl-4-­hydroxyphenyl)propionyloxy methyl]methane or 2,4-di-­isobutyl-6-(N,N-dimethylaminomethyl)-phenol.

  用于抑制白细胞介素-1的释放和缓解白细胞介素-1介导的病症（如IL-1介导的炎症）的方法，包括施用有效量的药学上可接受的抗氧化剂化合物，如双硫仑、四[3-(2,6-二叔丁基-4-羟基苯基)丙酰氧基甲基]甲烷或2,4-二异丁基-6-(N,N-二甲基氨基甲基)-苯酚。
• Gene transfer for treating a connective tissue of a mammalian host
  申请人：University of Pittsburgh of the Commonwealth System of Higher Education

  公开号：EP1932544A1

  公开（公告）日：2008-06-18

  The subject invention concerns a method of introducing at least one DNA sequence expressing a protein or protein fragment which substantially alleviates articular cartilage defects. This method involves in vitro culture of chondrocytes, transfection of the chondrocytes with a recombinant vector housing the DNA sequence to be expressed, and delivery of the transfected chondrocytes to the damaged cartilage region. This method can also be used in tandem with synovial cell delivery techniques of the present invention. This method is also useful as a model in animal studies regarding joint pathologies.

  本发明涉及一种引入至少一种表达蛋白质或蛋白质片段的 DNA 序列的方法，这种蛋白质或蛋白质片段可大大缓解关节软骨缺损。该方法包括体外培养软骨细胞，用含有待表达 DNA 序列的重组载体转染软骨细胞，以及将转染的软骨细胞输送到受损的软骨区域。这种方法也可与本发明的滑膜细胞递送技术结合使用。这种方法还可用作关节病理学动物研究的模型。
• Gene transfer for studying and treating a connective tissue of a mammalian host
  申请人：UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US20020098168A1

  公开（公告）日：2002-07-25

  Methods for introducing at least one gene encoding a product into at least one target cell of a mammalian host for use in treating the mammalian host are disclosed. These methods include employing recombinant techniques to produce a vector molecule that contains the gene encoding for the product, and infecting the target cells of the mammalian host using the DNA vector molecule. A method to produce an animal model for the study of connective tissue pathology is also disclosed.

  本发明公开了将至少一种编码产物的基因导入哺乳动物宿主的至少一种靶细胞以用于治疗哺乳动物宿主的方法。这些方法包括采用重组技术生产含有产品编码基因的载体分子，并使用 DNA 载体分子感染哺乳动物宿主的靶细胞。此外，还公开了一种用于研究结缔组织病理学的动物模型的生产方法。
• EP0563239A4
  申请人：——

  公开号：EP0563239A4

  公开（公告）日：1994-10-12