1-[4-[(4-Methoxy-3-propan-2-ylphenyl)methyl]-3,5-dimethylphenyl]pyrrolidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[4-[(4-Methoxy-3-propan-2-ylphenyl)methyl]-3,5-dimethylphenyl]pyrrolidine
• 化学式: C₂₃H₃₁NO
• 分子量: 337.5
• InChiKey: ORKGNDQNHXLLSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• BIARYL COMPOUNDS
  申请人：UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER

  公开号：EP1194422A1

  公开（公告）日：2002-04-10
• [EN] BIARYL COMPOUNDS<br/>[FR] COMPOSES BIARYLES
  申请人：UNIV TEXAS SOUTHWESTERN MED CT

  公开号：WO2000073292A1

  公开（公告）日：2000-12-07

  The present disclosure describes novel compounds and compositions which are particularly useful for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The compounds have a biphenyl structure as described in formula (I) and are preferably cardiac-sparing, and pharmaceutically acceptable salts, hydrates and biohydrolyzable amides, esters, and imides thereof, wherein, R1, R2, R3, R4, R5, R6, R6', R7, R8, R9, R10, Y, X, R11, and R12 are defined herein.