N,N-diethyl-4-[(2-phenoxyphenyl)-piperidin-4-ylidenemethyl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-diethyl-4-[(2-phenoxyphenyl)-piperidin-4-ylidenemethyl]benzamide
• 化学式: C₂₉H₃₂N₂O₂
• 分子量: 440.6
• InChiKey: FRBXMJPCJCPRLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF AS OPIOID RECEPTORS LIGANDS<br/>[FR] DERIVES DE DIARYLMETHYLIDENE PIPERIDINE, LEURS PREPARATIONS ET LEURS UTILISATIONS EN TANT QUE LIGANDS DU RECEPTEUR OPIOIDE
  申请人：ASTRAZENECA AB

  公开号：WO2004100952A1

  公开（公告）日：2004-11-25

  Compounds of general formula: (I) wherein R1, R2, R3 and A are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the treatment of pain and anxiety.

  通式为：（I）其中R1、R2、R3和A如规范中定义，以及包括这些化合物的盐、对映体以及制备的药物组合物。它们在治疗中很有用，特别是在疼痛和焦虑的治疗中。
• [EN] DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF<br/>[FR] DÉRIVÉS DIARYLMÉTHYLIDÈNE-PIPERIDINE, PROCÉDÉS D'ÉLABORATION ET D'UTILISATION CORRESPONDANTS
  申请人：ASTRAZENECA AB

  公开号：WO2004101519A1

  公开（公告）日：2004-11-25

  Compounds of general formula: Formula (I) wherein R1, R2, R3 and A are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

  通式化合物：通式（I），其中R1、R2、R3和A如规范中所定义，以及其盐、对映体和包括这些化合物的药物组合物已经制备。它们在治疗中很有用，特别是在疼痛管理方面。
• Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
  申请人：Brown William

  公开号：US20070066652A1

  公开（公告）日：2007-03-22

  Compounds of general formula: Formula (I) wherein R 1 , R 2 , R 3 and A are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

  通式为：Formula (I)的化合物，其中R1、R2、R3和A如规范中所定义，以及包括该化合物的盐、对映体和制药组合物已被制备。它们在治疗中很有用，特别是在疼痛管理方面。
• DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF
  申请人：AstraZeneca AB

  公开号：EP1626959A1

  公开（公告）日：2006-02-22
• DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF AS OPIOID RECEPTORS LIGANDS
  申请人：AstraZeneca AB

  公开号：EP1638564A1

  公开（公告）日：2006-03-29