1-[2-(2,4-dichloro-phenyl)-2-(4-fluoro-phenyl)-benzo[1,3]dioxole-5-sulfonyl]-piperidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[2-(2,4-dichloro-phenyl)-2-(4-fluoro-phenyl)-benzo[1,3]dioxole-5-sulfonyl]-piperidine
• 英文别名: 1-[[2-(2,4-Dichlorophenyl)-2-(4-fluorophenyl)-1,3-benzodioxol-5-yl]sulfonyl]piperidine
• 化学式: C₂₄H₂₀Cl₂FNO₄S
• 分子量: 508.398
• InChiKey: OTRVCDKCPXCCII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  64.2
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] NOVEL BENZODIOXOLES<br/>[FR] NOUVEAUX BENZODIOXOLES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004013120A1

  公开（公告）日：2004-02-12

  The present invention relates to compound of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases, which are associated with the modulation of CB1 receptors.

  本发明涉及具有式（I）的化合物，其中R1、R2、R3、R4、R5、R6、R7和X如描述和权利要求中所定义，并且其药学上可接受的盐。这些化合物可用于治疗和/或预防与CB1受体调节相关的疾病。
• [EN] 1,4-DIHYDRONAPHTHYRIDINE DERIVATIVES<br/>[FR] DÉRIVÉS DE 1,4-DIHYDRONAPHTYRIDINE
  申请人：PFIZER PROD INC

  公开号：WO2009056934A1

  公开（公告）日：2009-05-07

  A compound of formulae (I) or a prodrug of the compound or a pharmaceutically acceptable salt thereof of the compound or prodrug, wherein the substituents are as defined in the specification, pharmaceutical compositions containing the compounds useful as calcium channel antagonists, and to methods of treating heart disease and pain.

  一种化合物的公式（I）或该化合物的前药或其药用可接受的盐或前药，其中取代基如规范中所定义，含有该化合物的药用组合物可用作钙通道拮抗剂，并用于治疗心脏病和疼痛的方法。
• Diaryl Ether Derivatives and Uses Thereof
  申请人：Ruggeri B. Roger

  公开号：US20080070887A1

  公开（公告）日：2008-03-20

  Compounds of Formula (I) that act as antagonists at the mu, kappa and/or delta opioid receptors and therefore useful in the treatment of diseases, conditions and/or disorders that benefit from such antagonism in animals are described herein. where R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are described herein.

  本文描述了具有化学式（I）的化合物，这些化合物在mu、kappa和/或delta阿片受体上起拮抗作用，因此在动物治疗受益于这种拮抗作用的疾病、状况和/或障碍方面具有用处。其中R1、R2、R3、R4、R5和R6如下描述。
• Benzodioxole derivatives
  申请人：Alanine Alexander

  公开号：US20050143373A1

  公开（公告）日：2005-06-30

  The present invention relates to compounds of the general formula and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases such as obesity by selective modulation of CB1 receptors.

  本发明涉及一般式的化合物及其药学上可接受的盐。该化合物通过选择性调节CB1受体，对于治疗和/或预防肥胖等疾病是有用的。
• Diaryl, Dipyridinyl and Aryl-Pyridinyl Derivatives and Uses Thereof
  申请人：Ruggeri Roger B.

  公开号：US20080167371A1

  公开（公告）日：2008-07-10

  Compounds of Formula (I) that act as antagonists at the mu, kappa and/or delta opioid receptors and therefore useful in the treatment of diseases, conditions and/or disorders that benefit from such antagonism in animals are described herein. where R, R 1 , R 2a , R 2b , R 3 , R 4 , V, R 6 , R 7 , R 8 , R 9 , W and X are described herein.

  本文描述了化学式（I）的化合物，它们作为mu、kappa和/或delta阿片受体拮抗剂，因此对于需要这种拮抗作用的动物的疾病、状况和/或障碍的治疗是有用的。其中R、R1、R2a、R2b、R3、R4、V、R6、R7、R8、R9、W和X的描述在此处给出。