2-[1-[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3H-pyrrolo[3,2-d]pyrimidin-2-yl)phenyl]sulfonylpiperidin-4-yl]acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[1-[4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3H-pyrrolo[3,2-d]pyrimidin-2-yl)phenyl]sulfonylpiperidin-4-yl]acetic acid
• 化学式: C₂₅H₃₂N₄O₆S
• 分子量: 516.6
• InChiKey: VCEVXPFWXARWFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  139
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE
  申请人：SK Chemicals Co., Ltd.

  公开号：EP1257553B1

  公开（公告）日：2004-05-26
• COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR
  申请人：SK Chemicals Co., Ltd.

  公开号：US20140187775A1

  公开（公告）日：2014-07-03

  Disclosed is a composition effective in reducing skin wrinkles. The composition comprises a phosphodiesterase 5 (PDE5) inhibitor, preferably the compound of chemical formula 1, more preferably, mirodenafil as an active ingredient. Further disclosed is a method for reducing skin wrinkles using the composition.
• US6962911B2
  申请人：——

  公开号：US6962911B2

  公开（公告）日：2005-11-08
• US9271916B2
  申请人：——

  公开号：US9271916B2

  公开（公告）日：2016-03-01
• [EN] COMPOSITION FOR REDUCING SKIN WRINKLES INCLUDING PDE5 INHIBITOR<br/>[FR] COMPOSITION DESTINÉE À ATTÉNUER LES RIDES CUTANÉES CONTENANT UN INHIBITEUR DE LA PDE5
  申请人：SK CHEMICALS CO LTD

  公开号：WO2013036081A2

  公开（公告）日：2013-03-14

  Disclosed is a composition effective in reducing skin wrinkles. The composition comprisesa phosphodiesterase 5 (PDE5) inhibitor, preferably the compound of chemical formula 1, more preferably, mirodenafil as an active ingredient. Further disclosed is a method for reducing skin wrinkles using the composition.