(2-Chloro-3,4-dimethoxyphenyl)-N-({1-[(2-chlorophenyl)methyl]-4,5-dimethylimidazol-2-yl}methyl)-N-(3-methylbutyl)carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-Chloro-3,4-dimethoxyphenyl)-N-({1-[(2-chlorophenyl)methyl]-4,5-dimethylimidazol-2-yl}methyl)-N-(3-methylbutyl)carboxamide
• 英文别名: 2-chloro-N-[[1-[(2-chlorophenyl)methyl]-4,5-dimethylimidazol-2-yl]methyl]-3,4-dimethoxy-N-(3-methylbutyl)benzamide
• 化学式: C₂₇H₃₃Cl₂N₃O₃
• 分子量: 518.483
• InChiKey: ABGRAGSFQXQOBA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  56.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Substituted imidazoles as selective modulators of bradykinin B2 receptors
  申请人：——

  公开号：US20020115693A1

  公开（公告）日：2002-08-22

  Disclosed are compounds of the formula: 1 or the pharmaceutically acceptable non-toxic salts thereof wherein Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 R 7 ′ are variables defined herein, which compounds are modulators of Bradykinin B 2 receptors. These compounds are therefore useful in the diagnosis and treatment of renal diseases, heart failure, hypertension, Meniere's disease, vaginal inflammation and pain, peripheral circulatory disorders, climacteric disturbance, retinochoroidal circulatory disorders, myocardial ischemia, myocardial infarction, postmyocardial infarction syndrome, angina pectoris, restenosis after percutaneous transluminal coronary angioplasty, hepatitis, liver cirrhosis, pancreatitis, ileus, diabetes, diabetic complications, male infertility, glaucoma, pain, asthma, and rhinitis, and for the increase of permeability of the blood-brain barrier or the blood-brain-tumor barrier.

  本发明涉及式（1）的化合物或其药学上可接受的非毒性盐，其中Y、R1、R2、R3、R4、R5、R6、R7和R7′为所定义的变量，这些化合物是Bradykinin B2受体调节剂。因此，这些化合物可用于诊断和治疗肾脏疾病、心力衰竭、高血压、梅尼埃病、阴道炎症和疼痛、周围循环障碍、更年期障碍、视网膜脉络膜循环障碍、心肌缺血、心肌梗塞、心肌梗塞后综合症、心绞痛、经皮冠状动脉成形术后再狭窄、肝炎、肝硬化、胰腺炎、肠梗阻、糖尿病、糖尿病并发症、男性不育症、青光眼、疼痛、哮喘和鼻炎，并可增加血脑屏障或血脑肿瘤屏障的渗透性。
• US6509366B2
  申请人：——

  公开号：US6509366B2

  公开（公告）日：2003-01-21
• [EN] SUBSTITUTED IMIDAZOLES AS SELECTIVE MODULATORS OF BRADYKININ B2 RECEPTORS<br/>[FR] IMIDAZOLES SUBSTITUTES EN TANT QUE MODULATEURS SELECTIFS DES RECEPTEURS DE LA BRADYKININE B2
  申请人：NUEROGEN CORP

  公开号：WO2001056995A1

  公开（公告）日：2001-08-09

  Disclosed are compounds of formula (I): or the pharmaceutically acceptable non-toxic salts thereof wherein Y, R1, R2, R3, R4, R5, R6, R7 R7' are variables defined herein, which compounds are modulators of Bradykinin B2 receptors. These compounds are therefore useful in the diagnosis and treatment of renal diseases, heart failure, hypertension, Meniere's disease, vaginal inflammation and pain, peripheral circulatory disorders, climacteric disturbance, retinochoroidal circulatory disorders, myocardial ischemia, myocardial infarction, postmyocardial infarction syndrome, angina pectoris, restenosis after percutaneous transluminal coronary angioplasty, hepatitis, liver cirrhosis, pancreatitis, ileus, diabetes, diabetic complications, male infertility, glaucoma, pain, asthma, and rhinitis, and for the increase of permeability of the blood-brain barrier or the blood-brain-tumor barrier.