N-[(1S,2R,3R,4R)-5-(benzylamino)-1-(3,5-difluorobenzyl)-2,3-dihydroxy-4-methyl-5-oxopentyl]-2-[(methylsulfonyl)amino]-1,3-thiazole-4-carboxamide | 488805-23-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(1S,2R,3R,4R)-5-(benzylamino)-1-(3,5-difluorobenzyl)-2,3-dihydroxy-4-methyl-5-oxopentyl]-2-[(methylsulfonyl)amino]-1,3-thiazole-4-carboxamide
• 英文别名: N-[(2S,3R,4R,5R)-6-(benzylamino)-1-(3,5-difluorophenyl)-3,4-dihydroxy-5-methyl-6-oxohexan-2-yl]-2-(methanesulfonamido)-1,3-thiazole-4-carboxamide
• CAS: 488805-23-8
• 化学式: C₂₅H₂₈F₂N₄O₆S₂
• 分子量: 582.649
• InChiKey: JBWBEPGGKPQEHU-NCCCEKOESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  39
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  194
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• US7053109B2
  申请人：——

  公开号：US7053109B2

  公开（公告）日：2006-05-30
• [EN] AMINEDIOLS FOR THE TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] AMINODIOLS POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：ELAN PHARM INC

  公开号：WO2003006453A1

  公开（公告）日：2003-01-23

  The present invention relates to compounds of formula (I) useful in treating Alzheiner's disease and other similar diseases. These compounds include inhibitors of the betasecretase enzyme that are useful in the treatment of Alzheiner's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.