1,1,1-trifluoro-3-[N-[[3-(1,1,2,2,2-pentafluoroethyl)cyclohexyl]methyl]-3-[3-(trifluoromethoxy)phenoxy]anilino]propan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1,1-trifluoro-3-[N-[[3-(1,1,2,2,2-pentafluoroethyl)cyclohexyl]methyl]-3-[3-(trifluoromethoxy)phenoxy]anilino]propan-2-ol
• 化学式: C₂₅H₂₄F₁₁NO₃
• 分子量: 595.4
• InChiKey: BHOROJFNWDNANQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.9
• 重原子数：
  40
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  41.9
• 氢给体数：
  1
• 氢受体数：
  15

文献信息

• Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
  申请人：G.D. Searle & Co.

  公开号：US20030191306A1

  公开（公告）日：2003-10-09

  The invention relates to substituted N-Aliphatic-N-Aromatic tertiary-Heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis, dyslipidemia, and other coronary artery disease.

  该发明涉及取代的N-脂肪基-N-芳香族三元杂基胺化合物，可用作胆固醇酯转移蛋白（CETP;血浆脂质转移蛋白-I）的抑制剂，以及用于治疗动脉粥样硬化，血脂异常和其他冠状动脉疾病的化合物，组合物和方法。
• Pharmaceutical Compositions of Adsorbates of Amorphous Drug
  申请人：Babcock C. Walter

  公开号：US20070148236A1

  公开（公告）日：2007-06-28

  Pharmaceutical compositions comprise a low-solubility drug adsorbed onto a high surface area substrate to form an adsorbate. The compositions in some embodiments include a concentration-enhancing polymer.
• METHOD OF INHIBITING REMNANT LIPOPROTEIN PRODUCTION
  申请人：Okamoto Hiroshi

  公开号：US20110189210A1

  公开（公告）日：2011-08-04

  The present invention aims at provision of a method for inhibiting remnant lipoprotein production and a remnant lipoprotein production inhibitor, which includes administering a compound having a CETP inhibitory activity to an administration subject. The remnant lipoprotein production inhibitor of the present invention contains a compound having a CETP inhibitory activity as an active ingredient.
• US8236328B2
  申请人：——

  公开号：US8236328B2

  公开（公告）日：2012-08-07
• US8703199B2
  申请人：——

  公开号：US8703199B2

  公开（公告）日：2014-04-22