(3R)-3-(5-chloro-2-methoxypyridin-4-yl)sulfanyl-3-(1,2-oxazol-5-yl)propan-1-amine

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (3R)-3-(5-chloro-2-methoxypyridin-4-yl)sulfanyl-3-(1,2-oxazol-5-yl)propan-1-amine
• 化学式: C₁₂H₁₄ClN₃O₂S
• 分子量: 299.78
• InChiKey: GYJGPKCAEBRLDL-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  99.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• HETEROARYLHETEROALKYLAMINE DERIVATIVES AND THEIR USE AS INHIBITORS OF NITRIC OXIDE SYNTHASE
  申请人：AstraZeneca AB

  公开号：EP1414802B1

  公开（公告）日：2006-04-26
• JP2005501834A
  申请人：——

  公开号：JP2005501834A

  公开（公告）日：2005-01-20
• Heteroarylheteroalkylamine derivatives and their use as inhibitors of nitric oxide synthase
  申请人：——

  公开号：US20040176422A1

  公开（公告）日：2004-09-09

  There are provided novel compounds of formula (I), wherein R 1 , R 2 , R 3 , Q, T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
• [EN] HETEROARYLHETEROALKYLAMINE DERIVATIVES AND THEIR USE AS INHIBITORS OF NITRIC OXIDE SYNTHASE<br/>[FR] DERIVES D'HETEROARYLHETEROALKYLAMINE, ET LEUR UTILISATION COMME INHIBITEURS DE LA SYNTHASE DU MONOXYDE D'AZOTE
  申请人：ASTRAZENECA AB

  公开号：WO2003011830A1

  公开（公告）日：2003-02-13

  There are provided novel compounds of formula (I). wherein R?1, R2, R3¿, Q, T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.