trans-4-[2-(4-Phenylcyclohexylamino)ethyl]phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trans-4-[2-(4-Phenylcyclohexylamino)ethyl]phenol
• 英文别名: 4-[2-[(4-phenylcyclohexyl)amino]ethyl]phenol
• 化学式: C₂₀H₂₅NO
• 分子量: 295.4
• InChiKey: PLXOKPWSQRSVLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Cyclohexylamine derivatives as subtype selective nmda receptor antagonists
  申请人：——

  公开号：US20030225164A1

  公开（公告）日：2003-12-04

  Described are cyclohexylamine derivatives of Formula (I), Formula (II) or Formula (III) and their pharmaceutically acceptable salts thereof. The compounds are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, cerebral ischemia, cardiac arrest, stroke, and Parkinson's disease. The substituents are described in the specification. 1

  描述了公式(I)、公式(II)或公式(III)的环己胺衍生物及其药学上可接受的盐。这些化合物是NMDA受体通道复合物的拮抗剂，可用于治疗脑血管疾病，例如脑缺血、心脏骤停、中风和帕金森病。取代基在说明书中有描述。
• CYCLOHEXYLAMINE DERIVATIVES AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1296934A1

  公开（公告）日：2003-04-02
• US6765022B2
  申请人：——

  公开号：US6765022B2

  公开（公告）日：2004-07-20
• [EN] CYCLOHEXYLAMINE DERIVATIVES AS SUBTYPE SELECTIVE NMDA RECEPTOR ANTAGONISTS<br/>[FR] DERIVES DE CYCLOHEXYLAMINE UTILISES COMME ANTAGONISTES DES RECEPTEURS N-METHYL D-ASPARTATE DE NMDA SELECTIFS DE SOUS-TYPE.
  申请人：WARNER LAMBERT CO

  公开号：WO2001092204A1

  公开（公告）日：2001-12-06

  Described are cyclohexylamine derivatives of Formula (I), Formula (II) or Formula (III) and their pharmaceutically acceptable salts thereof. The compounds are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, cerebral ischemia, cardiac arrest, stroke, and Parkinson's disease. The substituents are described in the specification.