3-amino-2-(3,5-dimethoxyphenyl)-2,8-dihydro-6H-pyrano[3,4-c]pyridazine-4-carbonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-amino-2-(3,5-dimethoxyphenyl)-2,8-dihydro-6H-pyrano[3,4-c]pyridazine-4-carbonitrile
• 英文别名: 3-Amino-2-(3,5-dimethoxyphenyl)-6,8-dihydropyrano[3,4-c]pyridazine-4-carbonitrile
• 化学式: C₁₆H₁₆N₄O₃
• 分子量: 312.328
• InChiKey: BLAOYLFJQQWYKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  93.1
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Novel compounds
  申请人：——

  公开号：US20020115663A1

  公开（公告）日：2002-08-22

  The present invention is directed to novel pyridazine compounds of the formula I 1 as well as pharmaceutically and pharmacologically acceptable salts, and hydrates thereof; to a process for their preparation, their use and pharmaceutical compositions comprising said novel compounds. These novel compounds are useful in therapy, particularly for the treatment of type 2 diabetes mellitus.

  本发明涉及一种新型吡啶并嗪化合物，其化学式为I1，以及其药学和药理学上可接受的盐和水合物；以及它们的制备方法，用途和包含这些新型化合物的药物组合物。这些新型化合物在治疗中具有用途，特别是用于治疗2型糖尿病。
• [EN] NOVEL PYRIDAZINE COMPOUNDS FOR THE TREATMENT OF DIABETES<br/>[FR] NOUVEAUX COMPOSES DE PYRIDAZINE POUR LE TRAITEMENT DE DIABETES
  申请人：BIOVITRUM AB

  公开号：WO2002026743A1

  公开（公告）日：2002-04-04

  The present invention is directed to novel pyridazine compounds of the formula (I) as well as pharmaceutically and pharmaceutically acceptable salts, and hydrates thereof; to a process for their preparation, their use and pharmaceutical compositions comprising said novel compounds. These novel compounds are useful in therapy, particularly for the treatment of type 2 diabetes mellitus.