3-chloro-2-methyl-N-(4-methyl-5-propyl-1,3-thiazol-2-yl)benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-chloro-2-methyl-N-(4-methyl-5-propyl-1,3-thiazol-2-yl)benzenesulfonamide
• 化学式: C₁₄H₁₇ClN₂O₂S₂
• 分子量: 344.9
• InChiKey: LLKPYCDTFPVDSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  95.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-methyl-5-propylthiazol-2-amine 、 3-氯-2-甲基苯磺酰氯 、 生成 3-chloro-2-methyl-N-(4-methyl-5-propyl-1,3-thiazol-2-yl)benzenesulfonamide
  参考文献：
  名称：

  Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1

  摘要：

  本发明涉及式(I)的化合物，以及包含这些化合物的制药组合物，用于它们的制备过程，以及用于医学和制备对人类11-β-羟基类固醇脱氢酶1型酶起作用的药物的化合物的用途。

  公开号：

  US20030176476A1

文献信息

• Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
  申请人：——

  公开号：US20030176476A1

  公开（公告）日：2003-09-18

  The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-&bgr;-hydroxysteroid dehydrogenase type 1 enzyme.

  本发明涉及式(I)的化合物，以及包含这些化合物的制药组合物，用于它们的制备过程，以及用于医学和制备对人类11-β-羟基类固醇脱氢酶1型酶起作用的药物的化合物的用途。
• INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1
  申请人：BIOVITRUM AB

  公开号：EP1283833A1

  公开（公告）日：2003-02-19
• US7125900B2
  申请人：——

  公开号：US7125900B2

  公开（公告）日：2006-10-24
• [EN] INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1<br/>[FR] INHIBITEURS DE 11-BETA-HYDROXY-STEROIDE-DESHYDROGENASE DE TYPE 1
  申请人：BIOVITRUM AB

  公开号：WO2001090091A1

  公开（公告）日：2001-11-29

  The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
• [EN] NEW USE II<br/>[FR] NOUVELLE UTILISATION II
  申请人：BIOVITRUM AB

  公开号：WO2004112781A1

  公开（公告）日：2004-12-29

  The invention relates to a method for promoting wound healing, said method comprising administering to a mammal, including man, in need of such promotion an effective amount of an inhibitor of 11-b-hydroxysteroid dehydrogenase type 1 (11b-HSD1), said inhibitor having the formula (I) wherein A, B and T are as defined in the specification.