N'-[3-[[ethyl(2-hydroxyethyl)amino]methyl]-4-methylsulfanylphenyl]thiophene-2-carboximidamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-[3-[[ethyl(2-hydroxyethyl)amino]methyl]-4-methylsulfanylphenyl]thiophene-2-carboximidamide
• 化学式: C₁₇H₂₃N₃OS₂
• 分子量: 349.5
• InChiKey: NDHCEDSXCWIIGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  115
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] AMIDINE DERIVATIVES WHICH ARE INHIBITORS OF NITRIC OXIDE SYNTHASE<br/>[FR] DERIVES D'AMIDINE QUI SONT INHIBITEURS DE LA SYNTHASE D'OXYDE NITRIQUE
  申请人：ASTRAZENECA AB

  公开号：WO2002020511A1

  公开（公告）日：2002-03-14

  There are provided novel compounds of formula (I) wherein R1, R2, X, Y, W and Z are as defined in the Specification and optical isomers, racemates and tautomers thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme nitric oxide synthase.