1-(4-phenoxyphenyl)-1H-pyrazole-3-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-phenoxyphenyl)-1H-pyrazole-3-carboxamide
• 英文别名: 1-(4-phenoxyphenyl)pyrazole-3-carboxamide
• 化学式: C₁₆H₁₃N₃O₂
• 分子量: 279.298
• InChiKey: LGWCODVBNJMICU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-ethoxycarbonyl-1-(4-phenoxyphenyl)-1H-pyrazole 在 氨 作用下， 以 甲醇 为溶剂， 生成 1-(4-phenoxyphenyl)-1H-pyrazole-3-carboxamide
  参考文献：
  名称：

  Aryl substituted pyrazoles, triazoles, and tetrazoles, and the use thereof

  摘要：

  本发明涉及具有公式I:1的化合物，或其药学上可接受的盐、前药或溶剂，其中Het和R5-R8在说明书中设置。本发明还涉及使用公式I的化合物治疗全局性和局部性缺血后的神经损伤，治疗或预防神经退行性疾病，如肌萎缩性侧索硬化（ALS），以及治疗、预防或改善急性或慢性疼痛，作为抗耳鸣剂，抗癫痫药物和抗躁狂抑郁药物，作为局部麻醉剂，抗心律失常药物以及治疗或预防糖尿病性神经病变。

  公开号：

  US20020006947A1

文献信息

• Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof
  申请人：Euro-Celtique S.A.

  公开号：US20040002523A1

  公开（公告）日：2004-01-01

  This invention relates to compounds having the Formula I: 1 or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R 5 -R 8 are set in the specification. The invention also is directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

  本发明涉及具有式I：1的化合物，其中Het和R5-R8在规范中设置，或其药学上可接受的盐、前药或溶剂。本发明还涉及使用式I的化合物治疗全球和局部缺血后的神经损伤，治疗或预防神经退行性疾病，如肌萎缩性侧索硬化症（ALS），以及作为抗耳鸣剂，抗癫痫药物，抗躁狂抑郁药物，局部麻醉剂，抗心律失常药物以及治疗或预防糖尿病神经病变的药物。
• ARYL SUBSTITUTED PYRAZOLES, TRIAZOLES AND TETRAZOLES AS SODIUM CHANNEL BLOCKER
  申请人：Euro-Celtique S.A.

  公开号：EP1292577A2

  公开（公告）日：2003-03-19
• US6919363B2
  申请人：——

  公开号：US6919363B2

  公开（公告）日：2005-07-19
• US7078426B2
  申请人：——

  公开号：US7078426B2

  公开（公告）日：2006-07-18
• [EN] ARYL SUBSTITUTED PYRAZOLES, TRIAZOLES AND TETRAZOLES, AND THE USE THEREOF<br/>[FR] PYRAZOLES, TRIAZOLES ET TETRAZOLES A SUBSTITUTION ARYLE ET LEUR UTILISATION
  申请人：COCENSYS INC

  公开号：WO2001072714A2

  公开（公告）日：2001-10-04

  This invention relates to compounds having the Formula (I) or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Het and R5 - R8 are set in the specification. The invention also is directed to the use of compounds of Formula (I) for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.