N-[cyano(furan-2-yl)methyl]-2-(2,3-dichlorophenoxy)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[cyano(furan-2-yl)methyl]-2-(2,3-dichlorophenoxy)acetamide
• 化学式: C₁₄H₁₀Cl₂N₂O₃
• 分子量: 325.1
• InChiKey: ZCUZVCCCTSKMKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  75.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• ACETAMIDO ACETONITRILE DERIVATIVES AS INHIBITORS OF CATHEPSIN L AND/OR CATHEPSIN S
  申请人：AstraZeneca AB

  公开号：EP1155010A1

  公开（公告）日：2001-11-21
• [EN] ACETAMIDO ACETONITRILE DERIVATIVES AS INHIBITORS OF CATHEPSIN L AND/OR CATHEPSIN S<br/>[FR] DERIVES ACETAMIDO ACETONITRILES EN TANT QU'INHIBITEURS DE LA CATHEPSINE L ET/OU S
  申请人：ASTRAZENECA AB

  公开号：WO2000049007A1

  公开（公告）日：2000-08-24

  A compound of formula (I) wherein Ar, R?1, R2, R3, R4 and R5¿ are defined; a composition comprising a compound of formula (I) and a carrier or diluent; a compound of formula (I) for use as a medicament, the use of a compound of formula (I) in the manufacture of a medicament for use in the inhibition of a cysteine protease in a warn blooded animal; the use of a compound of formula (I) in the manufacture of a medicament for use in the treatment of chronic obstructive pulmonary disease in a warm blooded animal; and a method of treating a Cathepsin L or Cathepsin S mediated disease state in mammals which comprises administering to a mammal in need of such treatment an effective amount of a compound of formula (I).