2-amino-4-(2,5-dichlorophenyl)-6-morpholino-1,3,5-triazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-amino-4-(2,5-dichlorophenyl)-6-morpholino-1,3,5-triazine
• 英文别名: 4-(2,5-Dichlorophenyl)-6-morpholin-4-yl-1,3,5-triazin-2-amine
• 化学式: C₁₃H₁₃Cl₂N₅O
• 分子量: 326.185
• InChiKey: IIUZJJVKRQCFHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  77.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• TRIAZINE DERIVATIVE AND MEDICINE
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0775487A1

  公开（公告）日：1997-05-28

  A medicine containing as the active ingredient a triazine derivative represented by general formula (I), a solvate thereof, or a salt thereof and being useful as a hepatitis remedy, wherein R1 and R2 represent each independently hydrogen or (un)substituted alkyl, aralkyl or alkenyl, or NR1R2 represents a cyclic amino group which may bear, in addition to the pertinent nitrogen atom, nitrogen, oxygen or sulfur as the ring atom and may be substituted, provided the case where NR1R2 represents NH2 is excluded.

  一种含有通式(I)代表的三嗪衍生物、其溶液或其盐作为有效成分并可用于治疗肝炎的药物，其中R1和R2各自独立地代表氢或(未)取代的烷基、芳烷基或烯基，或NR1R2代表环状氨基，其环状原子除了相关的氮原子外，还可以是氮、氧或硫，并且可以被取代，但不包括NR1R2代表NH2的情况。
• REMEDY FOR PANCREATITIS
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0813874A1

  公开（公告）日：1997-12-29

  The invention relates to a therapeutic drug for pancreatitis which comprises a compound of the following general formula [I] or a salt thereof, or a solvate thereof. In the above formula, R1 and R2 may be the same or different and each represents hydrogen, alkyl which may be substituted, aralkyl, arylalkenyl, or aryl, or R1 and R2 taken together with the adjacent N atom, i.e. in the form of NR1R2, represent a 4- through 8-membered cyclic amino group, which cyclic amino group may contain nitrogen, oxygen, or sulfur as a ring member in addition to the above-mentioned N atom and may be further substituted.

  本发明涉及一种治疗胰腺炎的药物，它包括以下通式[I]的化合物或其盐，或其溶液。 在上式中，R1和R2可以相同或不同，各自代表氢、可被取代的烷基、芳烷基、芳烯基或芳基，或者R1和R2与相邻的N原子一起，即以NR1R2的形式，代表4-至8元环氨基，该环氨基除上述N原子外，还可含有氮、氧或硫作为环成员，并可进一步被取代。
• US5885993A
  申请人：——

  公开号：US5885993A

  公开（公告）日：1999-03-23
• US5962453A
  申请人：——

  公开号：US5962453A

  公开（公告）日：1999-10-05