N-cyclopentyl-N'-[(2-methoxyphenyl)methyl]-1-phenylethane-1,2-diamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-cyclopentyl-N'-[(2-methoxyphenyl)methyl]-1-phenylethane-1,2-diamine
• 化学式: C₂₁H₂₈N₂O
• 分子量: 324.5
• InChiKey: RANKZTRRIWPVSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  33.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Pharmaceutical agents for treatment of urinary incontinence
  申请人：PFIZER INC.

  公开号：EP0610021A1

  公开（公告）日：1994-08-10

  The present invention relates to a method of treating or preventing urinary incontinence in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane derivatives and related compounds.

  本发明涉及一种利用某些喹吖啶衍生物、哌啶衍生物、氮杂环戊烷衍生物及相关化合物治疗或预防哺乳动物（包括人类）尿失禁的方法。
• Substance P antagonists for the treatment of emesis
  申请人：PFIZER INC.

  公开号：EP0627221A2

  公开（公告）日：1994-12-07

  The present invention relates to compounds useful for treating or preventing emesis in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane derivatives and related compounds.

  本发明涉及利用某些喹吖啶衍生物、哌啶衍生物、氮杂环戊烷衍生物及相关化合物治疗或预防哺乳动物（包括人类）呕吐的化合物。
• Pharmaceutical agents for treatment or prevention of sunburn
  申请人：PFIZER INC.

  公开号：EP0653208A2

  公开（公告）日：1995-05-17

  The present invention relates to the use of certain quinuclidine derivatives, piperidine derivatives, azanorbornane derivatives and related compounds, for the manufacture of a medicament for the treatment or prevention of sunburn in a mammal (including a human being).

  本发明涉及使用某些喹吖啶衍生物、哌啶衍生物、氮杂环戊烷衍生物及相关化合物制造治疗或预防哺乳动物（包括人类）晒伤的药物。
• Substance P antagonists for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria
  申请人：PFIZER INC.

  公开号：EP0655246A1

  公开（公告）日：1995-05-31

  The present invention relates to a method treating or preventing disorders caused by a spiral urease-positive gram-negative bacterium such as Helicobacter pylori in mammals, including humans, using compounds that are substance P receptor antagonists and, specifically, using certain quinuclidine derivatives, piperidine derivatives, pyrrolidine derivatives, azanorbornane derivatives, ethylene diamine derivatives and related compounds.

  本发明涉及一种治疗或预防哺乳动物（包括人类）中由螺旋尿素酶阳性革兰氏阴性菌（如幽门螺旋杆菌）引起的疾病的方法，该方法使用的化合物是物质 P 受体拮抗剂，特别是使用某些奎宁环衍生物、哌啶衍生物、吡咯烷衍生物、氮基降冰片烷衍生物、乙二胺衍生物和相关化合物。
• Substance 1 antagonists for the inhibition of angiogenesis
  申请人：PFIZER INC.

  公开号：EP0659409A2

  公开（公告）日：1995-06-28

  The present invention relates to a methods of (a) inhibiting angiogenesis in mammal or (b) treating or preventing a disease or condition that is caused or mediated by angiogenesis or of which angiogenesis is a symptom in a mammal, using compounds that are substance P receptor antagonists and, specifically, certain quinuclidine derivatives, piperidine derivatives, pyrrolidine derivatives, azanorbornane derivatives, ethylene diamine derivatives and related compounds.

  本发明涉及使用 P 物质受体拮抗剂化合物，特别是某些喹啉衍生物、哌啶衍生物、吡咯烷衍生物、氮基降冰片烷衍生物、乙烯二胺衍生物及相关化合物，(a) 抑制哺乳动物体内的血管生成，或 (b) 治疗或预防由血管生成引起或介导的疾病或病症，或血管生成是哺乳动物体内的一种症状的方法。