(RS)-2-propylthio-1-phenylethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (RS)-2-propylthio-1-phenylethanol
• 英文别名: 1-phenyl-2-(propylthio)ethanol；1-phenyl-2-propylsulfanyl-ethanol；1-Phenyl-2-propylmercapto-aethanol；1-Phenyl-2-propylsulfanylethanol
• 化学式: C₁₁H₁₆OS
• 分子量: 196.313
• InChiKey: MIJWLAXZZYFPQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-phenyl-2-(propylthio)ethan-1-one 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 生成 (RS)-2-propylthio-1-phenylethanol
  参考文献：
  名称：

  Kinetic resolution of heteroaryl β-hydroxy sulfides catalyzed by Humicola lanuginosa lipase

  摘要：

  Humicola lanuginosa lipase-catalyzed resolution of heteroaryl substituted beta-hydroxy sulfides by irreversible transesterification using vinyl acetate as acylating agent is discussed. The ee of the resolved alcohols was determined from the H-1 NMR of their corresponding (S)-(+)-O-acetylmandelic acid esters. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(02)00148-9

文献信息

• Aerobic oxysulfonylation of alkenes using thiophenols: an efficient one-pot route to β-ketosulfones
  作者：Atul K. Singh、Ruchi Chawla、Twinkle Keshari、Vinod K. Yadav、Lal Dhar S. Yadav

  DOI：10.1039/c4ob00776j

  日期：——

  We have developed a highly efficient synthetic route to β-ketosulfones via AgNO3 catalyzed oxysulfonylation of alkenes using thiophenols in the presence of air (O2) and K2S2O8 as eco-friendly oxidants. Thiophenols have been used as sulfonylation precursors for the first time in a dioxygen activation based radical process. Moreover, the protocol also offers a new and convenient method for the synthesis

  我们已经开发出了一种高效的合成路线，该路线是在空气（O 2）和K 2 S 2 O 8作为生态友好型氧化剂的情况下，通过使用苯硫酚通过AgNO 3催化的烯烃的氧磺酰化反应。硫酚在基于双氧活化的自由基工艺中首次被用作磺酰化前体。此外，该方案还提供了一种在不使用任何引发剂的情况下，在室温下合成β-羟基硫化物的新型便捷方法。
• REACTIONS OF ATOMS AND FREE RADICALS IN SOLUTION. XXV. THE REACTIONS OF OLEFINS WITH MERCAPTANS IN THE PRESENCE OF OXYGEN¹
  作者：M. S. KHARASCH、W. NUDENBERG、G. J. MANTELL

  DOI：10.1021/jo01144a005

  日期：1951.4
• Kinetic resolution of heteroaryl β-hydroxy sulfides catalyzed by Humicola lanuginosa lipase
  作者：Swapandeep Singh Chimni、Satwinder Singh、Subodh Kumar、Savita Mahajan

  DOI：10.1016/s0957-4166(02)00148-9

  日期：2002.4

  Humicola lanuginosa lipase-catalyzed resolution of heteroaryl substituted beta-hydroxy sulfides by irreversible transesterification using vinyl acetate as acylating agent is discussed. The ee of the resolved alcohols was determined from the H-1 NMR of their corresponding (S)-(+)-O-acetylmandelic acid esters. (C) 2002 Elsevier Science Ltd. All rights reserved.