N-[[3-(3,3-dimethylpiperidin-1-yl)sulfonylphenyl]methyl]-1-(4-methylphenyl)methanamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[[3-(3,3-dimethylpiperidin-1-yl)sulfonylphenyl]methyl]-1-(4-methylphenyl)methanamine
• 化学式: C₂₂H₃₀N₂O₂S
• 分子量: 386.6
• InChiKey: RUESLIUFFSYUAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SULFONAMIDE SUBSTITUTED BENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICAMENTS
  申请人：ELI LILLY AND COMPANY LIMITED

  公开号：EP1200397A1

  公开（公告）日：2002-05-02
• [EN] SULFONAMIDE SUBSTITUTED BENZYLAMINE DERIVATIVES AND THEIR USE AS MEDICAMENTS<br/>[FR] DERIVES BENZYLAMINE SUBSTITUES DE SULFONAMIDES ET LEUR UTILISATION COMME MEDICAMENTS
  申请人：LILLY CO ELI

  公开号：WO2001004087A1

  公开（公告）日：2001-01-18

  A pharmaceutical compound of formula (I) in which the aminosulfonyl group is attached at the 3- or 4-position, and in which R1 is hydrogen, C¿1-6? alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl or optionally substituted phenyl-C1-4 alkyl, R?2¿ is C¿1-6? alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl, optionally substituted phenyl-C1-4 alkyl or -(CH2)2NR?5R6¿ where R?5 and R6¿ are each hydrogen or C¿1-6? alkyl, and R?3 and R4¿ are each C¿1-6? alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl, C3-6 alkenyl, optionally substituted phenyl or optionally substituted phenyl-C1-4 alkyl, or R?1 and R2, or R3 and R4, or R5 and R6¿, together with the nitrogen atom to which they are attached, form a carbocyclic group containing 4 to 7 carbon atoms optionally substituted with one to three methyl or ethyl groups and optionally containing an oxygen atom or a further nitrogen atom, said carbocyclic group being optionally fused to an optionally substituted phenyl group; or a salt thereof.