2-[(4-butoxyphenyl)sulfonylmethyl]-N,2-dihydroxy-3-[(5-methyl-1,2-oxazol-3-yl)methylsulfanyl]propanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(4-butoxyphenyl)sulfonylmethyl]-N,2-dihydroxy-3-[(5-methyl-1,2-oxazol-3-yl)methylsulfanyl]propanamide
• 化学式: C₁₉H₂₆N₂O₇S₂
• 分子量: 458.6
• InChiKey: UEUCINOYNNHAPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  30
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  173
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• ALPHA-HYDROXY,-AMINO AND -FLUORO DERIVATIVES OF BETA-SULPHONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS
  申请人：——

  公开号：US20030166687A1

  公开（公告）日：2003-09-04

  The present invention provides a compound of formula (1), or pharmaceutical acceptable salts thereof wherein R1 is C4-12 alkyl, C4-12 alkenyl, C4-12 alkynyl, —(CH2)h-C3-8 cycloalkyl, substituted and unsubstituted —(CH2)h-aryl, substituted and unsubstituted-(CH2)h-het, R2 is substituted and unsubstituted C1-12 alkyl, substituted and unsubstituted C2-12 alkenyl, substituted and unsubstituted C2-12 alkynyl, substituted and unsubstituted-(CH2)h-C3-8 cycloakyl, substituted and unsubstituted —(CH2)h-C3-8 unsubstituted-(CH2)h-C3-8 cycloakyl, substituted and unsubstituted —(CH2)h-C3-8 cycloalkenyl, substituted and unsubstituted-(CH2)h-aryl, substituted and unsubstituted-(CH2)h-heterocyclic ring, substituted and unsubstituted —(CH2)i-X—R4 (X is —O—, —S(═O)j-, —NR7-, —S(═O)2NR8-, or —C(═O)—), and —(CH2)iCHR5R6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation

  本发明提供了一种化合物，其化学式为（1），或其药物可接受的盐，其中R1为C4-12烷基，C4-12烯基，C4-12炔基，-(CH2)h-C3-8环烷基，取代和未取代的-(CH2)h-芳基，取代和未取代的-(CH2)h-杂环基，R2为取代和未取代的C1-12烷基，取代和未取代的C2-12烯基，取代和未取代的C2-12炔基，取代和未取代的-(CH2)h-C3-8环烷基，取代和未取代的-(CH2)h-C3-8未取代的-(CH2)h-C3-8环烷基，取代和未取代的-(CH2)h-C3-8环烯基，取代和未取代的-(CH2)h-芳基，取代和未取代的-(CH2)h-杂环环，取代和未取代的-(CH2)i-X-R4（X为—O—，—S(═O)j-，—NR7-，—S(═O)2NR8-，或—C(═O)—），以及-(CH2)iCHR5R6。这些化合物是参与组织降解的基质金属蛋白酶的抑制剂。
• $g(a)-HYDROXY, -AMINO, AND HALO DERIVATIVES OF $g(b)-SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASES INHIBITORS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1037868B1

  公开（公告）日：2003-02-05
• US6437177B1
  申请人：——

  公开号：US6437177B1

  公开（公告）日：2002-08-20