(RS)-N-(4-carbamimidoyl-2-carbamoylmethoxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide hydrochloride | 701266-01-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (RS)-N-(4-carbamimidoyl-2-carbamoylmethoxy-benzyl)-2-(2,6-difluoro-4-methoxy-phenyl)-2-ethoxy-acetamide hydrochloride
• 英文别名: N-[[2-(2-amino-2-oxoethoxy)-4-carbamimidoylphenyl]methyl]-2-(2,6-difluoro-4-methoxyphenyl)-2-ethoxyacetamide;hydrochloride
• CAS: 701266-01-5
• 化学式: C₂₁H₂₄F₂N₄O₅*ClH
• 分子量: 486.903
• InChiKey: PSRXUBUCTFMDRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.94
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  150
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Novel mandelic acid derivatives
  申请人：——

  公开号：US20040122057A1

  公开（公告）日：2004-06-24

  The invention is concerned with novel mandelic acid derivatives of formula (I) 1 wherein R 1 to R 10 , X and Y are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor.

  本发明涉及公式（I）1的新型苯甲酸衍生物，其中R1至R10，X和Y如说明书和权利要求中所定义，并且其药学上可接受的盐。这些化合物抑制由因子VIIa和组织因子诱导的凝血因子Xa，IXa和凝血酶的形成。
• MANDELIC ACID DERIVATIVES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1567498A2

  公开（公告）日：2005-08-31
• US7129238B2
  申请人：——

  公开号：US7129238B2

  公开（公告）日：2006-10-31
• [EN] MANDELIC ACID DERIVATIVES<br/>[FR] DERIVES D'ACIDE MANDELIQUE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004048335A2

  公开（公告）日：2004-06-10

  The invention is concerned with novel mandelic acid derivatives of formula (I), wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.