(1-Hydroxy-3-phosphono-3-pyrrolidin-1-ylpropyl)phosphonic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (1-Hydroxy-3-phosphono-3-pyrrolidin-1-ylpropyl)phosphonic acid
• 化学式: C₇H₁₇NO₇P₂
• 分子量: 289.16
• InChiKey: BWYKTNNRVNMPEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  139
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• PERCUTANEOUS PREPARATIONS
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP1475095A1

  公开（公告）日：2004-11-10

  A bisphosphonic acid derivative-containing percutaneous preparation of an excellent percutaneous permeability, comprising a bisphosphonic acid derivative such as incadronic acid, minodronic acid, etc., or pharmaceutically acceptable salts thereof, a solubilizing agent for the derivative or pharmaceutically acceptable salts thereof, and an amphiphilic solubilizing auxiliary agent, which may optionally contain a suspension-type base such as a polyvalent alcohol, a higher fatty acid ester, a liquid hydrocarbon or a vegetable oil, etc. This preparation has an excellent percutaneous permeability, reduces burdens on the patient, does not deteriorate the patient's compliance even in the administration over a prolonged period of time and can achieve the therapeutic effects in a short period of time.

  一种经皮渗透性极佳的含双膦酸衍生物的经皮制剂，包括一种双膦酸衍生物，如英卡膦酸、米诺膦酸等，或其药学上可接受的盐；一种用于该衍生物或其药学上可接受的盐的增溶剂；以及一种两性增溶辅助剂，该辅助剂可选择性地含有悬浮型基质，如多价醇、高级脂肪酸酯、液态烃或植物油等。这种制剂具有良好的经皮渗透性，可减轻患者的负担，即使长期给药也不会降低患者的依从性，并能在短时间内达到治疗效果。
• ADHESIVE PREPARATION
  申请人：Kyukyu Pharmaceutical Co., Ltd.

  公开号：EP2062584A1

  公开（公告）日：2009-05-27

  The present invention provides an adhesive preparation having a plaster layer disposed on a support, the adhesive preparation comprising at least one active ingredient selected from the group consisting of a bisphosphonic acid derivative, its salt thereof and a hydrate of either of the bisphosphonic acid derivative or the salt, a solubilizer for the active ingredient, propylene glycol, a hydrogenated terpene resin, an adhesive base, and a softening agent in the plaster layer.

  本发明提供了一种粘合剂制剂，其石膏层设置在支撑物上，该粘合剂制剂包括至少一种活性成分，该活性成分选自由双膦酸衍生物、其盐和双膦酸衍生物或盐的水合物、活性成分增溶剂、丙二醇、氢化萜烯树脂、粘合剂基料和石膏层中的软化剂组成的组。
• Percutaneous preparations
  申请人：Tsuji Yasuhiro

  公开号：US20050106186A1

  公开（公告）日：2005-05-19

  A bisphosphonic acid derivative-containing percutaneous preparation of an excellent percutaneous permeability, comprising a bisphosphonic acid derivative such as incadronic acid, minodronic acid, etc., or pharmaceutically acceptable salts thereof, a solubilizing agent for the derivative or pharmaceutically acceptable salts thereof, and an amphiphilic solubilizing auxiliary agent, which may optionally contain a suspension-type base such as a polyvalent alcohol, a higher fatty acid ester, a liquid hydrocarbon or a vegetable oil, etc. This preparation has an excellent percutaneous permeability, reduces burdens on the patient, does not deteriorate the patient's compliance even in the administration over a prolonged period of time and can achieve the therapeutic effects in a short period of time.
• Adhesive preparation
  申请人：Yamazaki Yuuhiro

  公开号：US20090239828A1

  公开（公告）日：2009-09-24

  The present invention provides an adhesive preparation having a plaster layer disposed on a support, the adhesive preparation comprising at least one active ingredient selected from the group consisting of a bisphosphonic acid derivative, its salt thereof and a hydrate of either of the bisphosphonic acid derivative or the salt, a solubilizer for the active ingredient, propylene glycol, a hydrogenated terpene resin, an adhesive base, and a softening agent in the plaster layer.
• US7820197B2
  申请人：——

  公开号：US7820197B2

  公开（公告）日：2010-10-26