1-Butyl-3-dodecyl-2-pyrrolidone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-Butyl-3-dodecyl-2-pyrrolidone
• 英文别名: 1-butyl-3-dodecylpyrrolidin-2-one
• 化学式: C₂₀H₃₉NO
• 分子量: 309.5
• InChiKey: QYNUTPXLQPAZBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  22
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• FORMULATION FOR ENHANCED TRANSDERMAL ABSORPTION OF DRUG
  申请人：UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

  公开号：US20190091168A1

  公开（公告）日：2019-03-28

  Provided is a transdermal formulation including a transdermal absorption enhancer including an aliphatic hydrocarbon derivative and a pyrrolidone derivative; and a benzene diamine derivative for preventing or treating dementia, Alzheimer's disease, and hair loss.

  提供的是一种透皮制剂，包括一种透皮吸收增强剂，其中包括一种脂肪族碳氢化合物衍生物和一种吡咯烷酮衍生物；以及一种苯二胺衍生物，用于预防或治疗痴呆症、阿尔茨海默病和脱发。
• PROCESS FOR PREPARING CHLORINS AND THEIR PHARMACEUTICAL USES
  申请人：Da Silva Arnaut Moreira Luis Guilherme

  公开号：US20110250143A1

  公开（公告）日：2011-10-13

  The disclosed subject matter includes methods of preparation, properties, pharmaceutical compositions and methods of therapy of sulfonated chlorins and bacterioclorins designed for the photodynamic therapy (PDT) of hyperproliferative tissues such as tumors, hyperproliferative blood vessels and other disorders or abnormalities that are responsive to PDT. In particular, the economical large-scale synthesis of stable chlorins and bacteriochlorins is described. Their properties were tailored to meet those of ideal photosensitizers for PDT. In another embodiment, pharmaceutical compositions and methods of therapy for systemic administration are provided. In a further embodiment, pharmaceutical compositions and methods of therapy for topical administration are also provided. Further provided is a method of labeling a target tissue and providing an image of that tissue by fluorescence of magnetic resonance imaging.

  本公开的主题包括制备方法、性质、药物组成和治疗方法，用于光动力疗法（PDT）治疗过度增生组织，如肿瘤、过度增生的血管和其他对PDT有响应的疾病或异常。特别地，描述了稳定的叶绿素和细菌叶绿素的经济大规模合成。它们的性质被调整以满足理想的光敏剂的要求。在另一实施例中，提供了用于全身给药的药物组成和治疗方法。在另一实施例中，还提供了用于局部给药的药物组成和治疗方法。此外，还提供了一种通过荧光或磁共振成像标记目标组织并提供该组织图像的方法。
• (R)-2-(3-fluoro-4-phenylphenyl)propionic acid for use in the treatment of skin diseases
  申请人：GALENpharma GmbH

  公开号：EP2468270A1

  公开（公告）日：2012-06-27

  The present invention relates to (R)-2-(3-fluoro-4-phenylphenyl)propionic acid (tarenflurbil) or a pharmaceutically acceptable salt, solvate or ester thereof for use in the treatment of inflammation and/or itching of the skin as well as a pharmaceutical composition comprising tarenflurbil.

  本发明涉及用于治疗皮肤炎症和/或瘙痒的(R)-2-(3-氟-4-苯基苯基)丙酸（tarenflurbil）或其药学上可接受的盐、溶液或酯，以及包含 tarenflurbil 的药物组合物。
• TRANSDERMAL PREPARATION CONTAINING DONEPEZIL AS ACTIVE INGREDIENT
  申请人：Icure Pharmaceutical Inc.

  公开号：EP3235494A1

  公开（公告）日：2017-10-25

  The present invention relates to a transdermal composition for dementia treatment containing donepezil as an active ingredient. The transdermal composition according to the present invention contains highly concentrated donepezil in a hydrophobic matrix, can continuously release the drug for a long time by having excellent long-term adhesion to the skin, and further exhibits consistently effective therapeutic effects over a long period of time by having a significantly improved skin penetration rate in comparison with conventional donepezil patches.

  本发明涉及一种用于治疗痴呆症的透皮组合物，其中含有作为活性成分的多奈哌齐。本发明的透皮组合物在疏水基质中含有高浓度的多奈哌齐，与皮肤的长期粘附性极佳，可长期持续释放药物，与传统的多奈哌齐贴剂相比，皮肤渗透率显著提高，可长期持续显示有效的治疗效果。
• Delivery of drug nanoparticles and methods of use thereof
  申请人：DFB Soria, LLC

  公开号：US10449162B2

  公开（公告）日：2019-10-22

  Disclosed are compositions and methods useful for enhancing the skin penetration of drug nanoparticles. The compositions can be hydrophobic and include a hydrophobic carrier, a volatile silicone fluid, and drug nanoparticles. Also disclosed are methods for inhibiting crystal growth of drug nanoparticles in an aqueous carrier or a hydrophobic carrier. Further, methods to topically treat psoriasis using compositions containing nanoparticles of paclitaxel or other taxanes are disclosed.

  所公开的是用于增强药物纳米粒子皮肤渗透性的组合物和方法。这些组合物可以是疏水性的，包括疏水载体、挥发性硅油和药物纳米粒子。还公开了在水性载体或疏水性载体中抑制药物纳米粒子晶体生长的方法。此外，还公开了使用含有紫杉醇或其他类固醇的纳米颗粒的组合物局部治疗牛皮癣的方法。