[5-(4-Bromo-thiophen-3-yl)-1H-pyrazol-3-yl]-phenyl-amine | 369370-08-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [5-(4-Bromo-thiophen-3-yl)-1H-pyrazol-3-yl]-phenyl-amine
• 英文别名: 5-(4-bromothiophen-3-yl)-N-phenyl-1H-pyrazol-3-amine
• CAS: 369370-08-1
• 化学式: C₁₃H₁₀BrN₃S
• 分子量: 320.212
• InChiKey: SVKVXDJRHPPHIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• PYRAZOLES FOR INHIBITING PROTEIN KINASES
  申请人：AGOURON PHARMACEUTICALS, INC.

  公开号：EP1274706A1

  公开（公告）日：2003-01-15
• [EN] PYRAZOLES FOR INHIBITING PROTEIN KINASE<br/>[FR] PYRAZOLES PERMETTANT D'INHIBER DES PROTEINES KINASES
  申请人：AGOURON PHARMA

  公开号：WO2001079198A1

  公开（公告）日：2001-10-25

  Amino-pyrazole compounds of formula (I), that modulate and/or inhibit the activity of protein kinases. These compounds and pharmaceutical compositions containing them are capable of mediating and/or inhibiting the activity cyclin-dependent kinases, thereby modulating and/or inhibiting unwanted cell proliferation. The invention is also directed to the therapeutic or prophylatic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.