1-Benzyl-4-(hydroxymethyl)-3-methyl-5-pyridin-4-ylsulfanylimidazol-2-one

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 1-Benzyl-4-(hydroxymethyl)-3-methyl-5-pyridin-4-ylsulfanylimidazol-2-one
• 化学式: C₁₇H₁₇N₃O₂S
• 分子量: 327.4
• InChiKey: NTBHLBFFVIZBGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  82
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Anti-HIV imidazolone derivatives
  申请人：——

  公开号：US20020107272A1

  公开（公告）日：2002-08-08

  The invention is concerned with novel imidazolone derivatives, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds are inhibitors of the human immunodeficiency virus reverse transcriptase enzyme which is involved in viral replication. Consequently the compounds of this invention may be advantageously used as therapeutic agents against HIV infection.

  本发明涉及新型咪唑酮衍生物，其制备方法，药物组合物以及在医学中使用这些化合物。具体来说，这些化合物是人类免疫缺陷病毒逆转录酶的抑制剂，该酶参与病毒复制。因此，本发明的化合物可以优势地用作治疗HIV感染的治疗剂。
• IMIDAZOLONE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1341766B1

  公开（公告）日：2005-10-26
• US6518293B2
  申请人：——

  公开号：US6518293B2

  公开（公告）日：2003-02-11
• [EN] IMIDAZOLONE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES<br/>[FR] DERIVES D'IMIDAZOLONE POUR LE TRAITEMENT DE MALADIES VIRALES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2002042279A1

  公开（公告）日：2002-05-30

  The invention describes novel imidazolone derivatives as well as hydrolyzable esters or ethers of compounds of formula I and pharmaceutically acceptable salts thereof, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine (formula I) wherein R?1, R2, R3¿, A and X are as defined in the description. The compounds of formula I are the human immunodeficiency virus reverse transcriptase enzyme which is involved in viral replication. Consequently the compounds of this invention may be advantageously used as therapeutic agents for HIV madiated process.